{"id":58110,"date":"2018-03-09T22:45:58","date_gmt":"2018-03-09T22:45:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citrulina-plasmatica-como-marcador-de-atrofia-vellositaria-en-ninos\/"},"modified":"2018-03-09T22:45:58","modified_gmt":"2018-03-09T22:45:58","slug":"citrulina-plasmatica-como-marcador-de-atrofia-vellositaria-en-ninos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/citrulina-plasmatica-como-marcador-de-atrofia-vellositaria-en-ninos\/","title":{"rendered":"Citrulina plasm\u00e1tica como marcador de atrofia vellositaria en ni\u00f1os"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Blasco Alonso <\/strong><\/h2>\n<p>Introducci\u00f3n     existe gran catabolismo intestinal de amino\u00e1cidos. La citrulina plasm\u00e1tica, amino\u00e1cido no proteico derivado del metabolismo de la glutamina por los enterocitos v\u00eda glutamato-ornitina, se ha propuesto como indicador de la masa de enterocitos en el s\u00edndrome de intestino corto, expresando de ese modo el grado funcional del intestino restante. Aunque participa del ciclo del a urea en el h\u00edgado en el h\u00edgado, el intestino delgado es la fuente para gran parte dela citrulina encontrada en la circulaci\u00f3n. al no estar incorporada a las prote\u00ednas end\u00f3genas ni ex\u00f3genas constituye un te\u00f3rico marcador de la atrofia vellositaria.  el objetivo del estudio es relacionar los niveles plasm\u00e1ticos de citrulina y arginina con la severidad de la afectaci\u00f3n de la mucosa intestinal en pacientes celiacos.  material y m\u00e9todos     estudio observacional longitudinal de casos-controles en ni\u00f1os entre 16 meses y 14 a\u00f1os: 46 con atrofia vellositaria debida a enfermedad cel\u00edaca (28 con atrofia parcial y 18 con atrofia total) 9 cel\u00edacos con normalizaci\u00f3n cl\u00ednica y anal\u00edtica siguiendo dieta sin gluten, 10 ni\u00f1os afectos de enfermedad de crohn con afectaci\u00f3n significativa de intestino delgado y 8 con formas de enfermedad inflamatoria intestinal de colitis exclusiva, con un grupo control de 42 ni\u00f1os sanos no cel\u00edacos como controles. Se determina concentraciones plasm\u00e1ticas de amino\u00e1cidos, en umol\/l y variables cl\u00ednicas y anal\u00edticas asociadas, destacando especialmente la grasa en heces de 24h y la calprotectina fecal.  resultados y discusi\u00f3n     edades medias similares en casos y controles por lo que las diferencias encontradas en concentraciones de amino\u00e1cidos no son achacables a diferente cantidad de masa intestinal en funci\u00f3n de edad.  similares \u00edndices de masas corporal en cel\u00edacos con atrofia y en enfermos de crohn indican afectaci\u00f3n nutricional discreta, por ser formas asintom\u00e1tica u oligosintom\u00e1tica en muchos casos. La cirtulina<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citrulina plasm\u00e1tica como marcador de atrofia vellositaria en ni\u00f1os<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citrulina plasm\u00e1tica como marcador de atrofia vellositaria en ni\u00f1os <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Blasco Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Sierra Salinas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio M\u00e1rtinez valverde <\/li>\n<li>federico Arguelles martin (vocal)<\/li>\n<li>angel Gil hernandez (vocal)<\/li>\n<li>Jos\u00e9 angel Aguirre gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Blasco Alonso Introducci\u00f3n existe gran catabolismo intestinal de amino\u00e1cidos. La citrulina plasm\u00e1tica, amino\u00e1cido no proteico derivado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2931,491,7834],"tags":[3791,2402,100581,1840,128398,8108],"class_list":["post-58110","post","type-post","status-publish","format-standard","hentry","category-enfermedades-de-la-nutricion","category-gastroenterologia","category-malaga","tag-angel-gil-hernandez","tag-antonio-Martinez-valverde","tag-carlos-sierra-salinas","tag-federico-arguelles-martin","tag-javier-blasco-alonso","tag-jose-angel-aguirre-gomez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58110"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58110\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}