{"id":5813,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/analisis-molecular-de-la-expresion-mchc-en-lineas-tumorales-de-pancreas\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"analisis-molecular-de-la-expresion-mchc-en-lineas-tumorales-de-pancreas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-molecular-de-la-expresion-mchc-en-lineas-tumorales-de-pancreas\/","title":{"rendered":"Analisis molecular de la expresion mchc en lineas tumorales de pancreas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Torres Crespo M. Jose <\/strong><\/h2>\n<p>Hemos usado diversas tecnicas inmunohistoquimicas, bioquimicas y dna recombinante para investigar la alteracion de la expresion hla de clase i en cinco lineas tumorales de pancreas. Las perdidas hla eran comparables a los datos obtenidos en otros tejidos (mayores a 35%) usando anticuerpos monomorficos y locus especificos. En un paciente disponiamos del tumor solido, la linea celular derivada de el y linfocitos transformados con el virus de ebstein bar. Hemos demostrado perdidas de los alelos a30 y b14 tanto en el tejido tumoral como en la linea celular derivada de este. El analisis mediante secuenciacion de clonos de dna genomico y cdna confirmo la perdida de expresion a causa de la perdida de ambos genes. Se estudiaron otros locus polimorficos del cromosoma 6 y sugerian la deleccion de material genetico.  esta alteracion hla sugiere un nuevo mecanismo de produccion, de perdidas de expresion de antigenos hla.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis molecular de la expresion mchc en lineas tumorales de pancreas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis molecular de la expresion mchc en lineas tumorales de pancreas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Torres Crespo M. Jose <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>cabello  Osuna Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Solana Lara <\/li>\n<li>Jos\u00e9 Mar\u00eda no Ruiz De Almodovar (vocal)<\/li>\n<li>Francisco Xavier Real Arribas (vocal)<\/li>\n<li>Fernando Vidal Vanaclocha (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Torres Crespo M. Jose Hemos usado diversas tecnicas inmunohistoquimicas, bioquimicas y dna recombinante para investigar la alteracion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1738,35,1737,2953],"tags":[4019,12983,13679,4385,3760,22432],"class_list":["post-5813","post","type-post","status-publish","format-standard","hentry","category-antigenos","category-ciencias-de-la-vida","category-inmunologia","category-trasplante-de-organos","tag-cabello-osuna-ruiz","tag-fernando-vidal-vanaclocha","tag-francisco-xavier-real-arribas","tag-jose-maria-no-ruiz-de-almodovar","tag-rafael-solana-lara","tag-torres-crespo-m-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/5813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=5813"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/5813\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=5813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=5813"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=5813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}