{"id":58148,"date":"2018-03-09T22:45:58","date_gmt":"2018-03-09T22:45:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analysis-of-genetic-variation-in-candidate-genes-for-functional-psychosis-an-approach-based-on-endophenotypes-and-clinical-features\/"},"modified":"2018-03-09T22:45:58","modified_gmt":"2018-03-09T22:45:58","slug":"analysis-of-genetic-variation-in-candidate-genes-for-functional-psychosis-an-approach-based-on-endophenotypes-and-clinical-features","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analysis-of-genetic-variation-in-candidate-genes-for-functional-psychosis-an-approach-based-on-endophenotypes-and-clinical-features\/","title":{"rendered":"Analysis of genetic variation in candidate genes for functional psychosis: an approach based on endophenotypes and clinical features"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergi Papiol Mir\u00f3 <\/strong><\/h2>\n<p>El objetivo general de la presente tesis fue estudiar genes candidatos de inter\u00e9s como factores de riesgo para la esquizofrenia y el trastorno bipolar.     en esta tesis se ha analizado el efecto de determinadas variantes en dichos genes candidatos tanto sobre el riesgo para sufrir estos trastornos mentales graves como para presentar determinadas caracter\u00edsticas neuroanat\u00f3micas y funcionales del cerebro que suelen observarse en estos pacientes.     en este sentido, el an\u00e1lisis de genes candidatos ha puesto de manifiesto que determinadas variantes gen\u00e9ticas de lso genes il-1 beta e il-1rn, situados en el il-1 cluster (cromosoma 2q13), ser\u00edan un factor de riesgo compartido entre los diagn\u00f3sticos de esquizofrenia y trastorno bipolar. Adicionalmente, se han relacionado algunas de estas variantes con la dilataci\u00f3n de los ventr\u00edculos cerebrales y un hipofunci\u00f3n frontal en esquizofrenia y los d\u00e9ficits de materia fris en regiones frontales en trastorno bipolar. Por otro lado, en an\u00e1lisis del gen tp53 no revel\u00f3 ning\u00fan efecto gen\u00e9tico sobre la esquizofrenia ni sobre variables neurocognitivas frecuentemente alteradas en este trastorno.     esta tesis confirma que existir\u00edan factores de riesgo gen\u00e9tico compartido entre esquizofrenia y trastorno bipolar con una repercusi\u00f3n tanto neuroanat\u00f3mica como sobre la funci\u00f3n cerebral que podr\u00eda explicar, al menos, parte de la compleja manifestaci\u00f3n fenot\u00edpica de estos trastornos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analysis of genetic variation in candidate genes for functional psychosis: an approach based on endophenotypes and clinical features<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analysis of genetic variation in candidate genes for functional psychosis: an approach based on endophenotypes and clinical features <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergi Papiol Mir\u00f3 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lourdes Fa\u00f1an\u00e1s  Saura<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Vicente (secretario) Molina Rodriguez <\/li>\n<li>Victor Peralta Martin (vocal)<\/li>\n<li>Igor Nenadic (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergi Papiol Mir\u00f3 El objetivo general de la presente tesis fue estudiar genes candidatos de inter\u00e9s como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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