{"id":5815,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/caracterizacion-del-gen-de-la-clusterina-murino-y-regulacion-de-su-expresion-genica-en-celulas-tumorales-murinas-ma-10\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"caracterizacion-del-gen-de-la-clusterina-murino-y-regulacion-de-su-expresion-genica-en-celulas-tumorales-murinas-ma-10","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-del-gen-de-la-clusterina-murino-y-regulacion-de-su-expresion-genica-en-celulas-tumorales-murinas-ma-10\/","title":{"rendered":"Caracterizacion del gen de la clusterina murino y regulacion de su expresion genica en celulas tumorales murinas ma-10."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Torres Mu\u00f1oz Jorge  Enrique <\/strong><\/h2>\n<p>Se clonan dos fragmentos de cdna del gen de la clusterina murino denominados palfa-clus i y pbeta-clus ii, representando casi la totalidad del mrna del mencionado gen, a partir de mrna aislado de las celulas tumorales de leydig ma-10.Mediante secuenciacion del cdna y comparacion con la secuencia de dna del mismo gen se determina que el gen de la clusterina murino contiene 9 exones y 8 intrones y presenta una similitud del 90,4% y 64,6% con sus homologos de rata y humano.Se demuestra el efecto inhibitorio especifico ejercido por el camp sobre la expresion del mrna del gen de la clusterina en las mencionadas celulas, ademas de un efecto sinergico inhibitorio al combinar el camp con otras sustancias, a saber: testosterona, (test-camp) factor de crecimiento epidermal (egf) (egf-camp) y el ester de forbol conocido como tpa (tpa-camp), sugiriendo que este nucleotido tiene mas de un mecanismo tanto directo como indirecto de accion para ejercer la regulacion de la expresion genica.Nuestros resultados tambien sugieren que la testosterona ejerce una accion autocrina y confirma la importancia del egf al inhibir la expresion del mrna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion del gen de la clusterina murino y regulacion de su expresion genica en celulas tumorales murinas ma-10.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion del gen de la clusterina murino y regulacion de su expresion genica en celulas tumorales murinas ma-10. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Torres Mu\u00f1oz Jorge  Enrique <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Josefa Liboria Segovia Parra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Nogales <\/li>\n<li>M\u00e1ximino Redondo Bautista (vocal)<\/li>\n<li>Miguel Morell (vocal)<\/li>\n<li>Armando Zuloaga Gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Torres Mu\u00f1oz Jorge Enrique Se clonan dos fragmentos de cdna del gen de la clusterina murino denominados [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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