{"id":58150,"date":"2018-03-09T22:45:58","date_gmt":"2018-03-09T22:45:58","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-disminucion-de-la-temperatura-corporal-en-la-progresion-del-dano-hepatico-agudo-inducido-por-paracetamol-en-ratones\/"},"modified":"2018-03-09T22:45:58","modified_gmt":"2018-03-09T22:45:58","slug":"efectos-de-la-disminucion-de-la-temperatura-corporal-en-la-progresion-del-dano-hepatico-agudo-inducido-por-paracetamol-en-ratones","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-disminucion-de-la-temperatura-corporal-en-la-progresion-del-dano-hepatico-agudo-inducido-por-paracetamol-en-ratones\/","title":{"rendered":"Efectos de la disminuci\u00f3n de la temperatura corporal en la progresi\u00f3n del da\u00f1o hep\u00e1tico agudo inducido por paracetamol en ratones"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Vaquero Martin <\/strong><\/h2>\n<p>Introducci\u00f3n: la inducci\u00f3n de hipotermia leve (~32~34 \u00c2\u00bac) previene las complicaciones neurol\u00f3gicas del fallo hep\u00e1tico agudo en estudios experimentales y en estudios cl\u00ednicos preliminares. Su efecto sobre el da\u00f1o y la regeneraci\u00f3n hep\u00e1tica, sin embargo, no ha sido estudiado con detalle, lo cual causa preocupaci\u00f3n cara a su uso cl\u00ednico. Objetivos: estudiar el efecto de la hipotermia leve sobre la progresi\u00f3n del da\u00f1o hep\u00e1tico agudo inducido por paracetamol en ratones y sobre la regeneraci\u00f3n hep\u00e1tica. Dise\u00f1o experimental: tras 16 h de ayuno, ratones c57bi6 (20-25 g peso corporal) fueron tratados con paracetamol (300 mg\/kg i.P.) O suero salino. Tras la inyecci\u00f3n, los ratones fueron mantenidos normot\u00e9rmicos (t\u00aa rectal:35.5-37.5 \u00c2\u00bac) en las primeras 2 h con una l\u00e1mpara\/colchoneta t\u00e9rmica; posteriormente, un grupo continu\u00f3 normot\u00e9rmico y a otro grupo le permitamos desarrollar hipotermia leve (t\u00aa rectal:32.5-34.5 \u00c2\u00bac). Resultados: la reducci\u00f3n de la temperatura corporal previno la mortalidad y redujo el da\u00f1o hep\u00e1tico inducido por la sobredosis de paracetamol, evaluado histol\u00f3gicamente y por la mediaci\u00f3n de las aminotransferasas en plasma. El efecto hepatoprotector de la hipotermia leve se asoci\u00f3 a una mayor y m\u00e1s temprana recuperaci\u00f3n de la depleci\u00f3n de gluc\u00f3geno hep\u00e1tico inducida por el paracetamol, as\u00ed como a una atenuaci\u00f3n precoz del desarrollo de congesti\u00f3n y hemorragia hep\u00e1tica (evaluada por an\u00e1lisis histol\u00f3gico y por la medici\u00f3n de la concentraci\u00f3n de hemoglobina en tejido hep\u00e1tico). De forma m\u00e1s tard\u00eda, la reducci\u00f3n de la temperatura corporal tambi\u00e9n atenu\u00f3 la infiltraci\u00f3n del tejido hep\u00e1tico por neutr\u00f3filos y modul\u00f3 la expresi\u00f3n de citocinas y genes hepatoprotectores hacia un perfil favorable. En concreto, la hipotermia leve previno la inducci\u00f3n de la citocina pro-inflamatoria il-1beta en el par\u00e9nquima hep\u00e1tico, pero no previno la inducci\u00f3n de il-6, il-10 ni de hemoxigenasa-1 (prote\u00ednas con importantes funci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la disminuci\u00f3n de la temperatura corporal en la progresi\u00f3n del da\u00f1o hep\u00e1tico agudo inducido por paracetamol en ratones<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la disminuci\u00f3n de la temperatura corporal en la progresi\u00f3n del da\u00f1o hep\u00e1tico agudo inducido por paracetamol en ratones <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Vaquero Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Ba\u00f1ares Ca\u00f1izares<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Millan nu\u00f1ez cortes <\/li>\n<li>Juan C\u00f3rdoba carmona (vocal)<\/li>\n<li>agust\u00edn Albillos mart\u00ednez (vocal)<\/li>\n<li>Jes\u00fas Fr\u00edas iniesta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Vaquero Martin Introducci\u00f3n: la inducci\u00f3n de hipotermia leve (~32~34 \u00c2\u00bac) previene las complicaciones neurol\u00f3gicas del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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