{"id":58177,"date":"2018-03-09T22:46:02","date_gmt":"2018-03-09T22:46:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismos-geneticos-en-promotores-de-metaloproteasas-y-riesgo-de-cancer-de-pulmon\/"},"modified":"2018-03-09T22:46:02","modified_gmt":"2018-03-09T22:46:02","slug":"polimorfismos-geneticos-en-promotores-de-metaloproteasas-y-riesgo-de-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/polimorfismos-geneticos-en-promotores-de-metaloproteasas-y-riesgo-de-cancer-de-pulmon\/","title":{"rendered":"Polimorfismos geneticos en promotores de metaloproteasas y riesgo de cancer de pulmon"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Gonzalez Arriaga <\/strong><\/h2>\n<p>El c\u00e1ncer de pulm\u00f3n representa uno de los principales problemas de salud en pa\u00edses industrializados. Su desarrollo se debe fundamentalmente a la influencia de factores ambientales, como el tabaco, que constituye el principal factor de riesgo. Apesar de esto, diversos estudios sugieren la existencia de factores gen\u00e9ticos que contribuyen al desarrollo y la evoluci\u00f3n del c\u00e1ncer de pulm\u00f3n. Las metaloproteasas de matriz extracelular (mmps) son proteasas capaces de degradar todos los componentes de la matriz extracelular, por lo que su expresi\u00f3n est\u00e1 aumentada en numerosos procesos tumorales. En este trabajo se ha investigado la relaci\u00f3n entre polimorfismos en el promotor del gen de las mmps, pertenecientes a las familias de las colagenasas (-1607 1g\/2g mmp1, +17 c\/g mmp8 y -77 a\/g mmp13), las gelatinasas (-735 c\/t mmp2 y -1562 c\/t mmp9) y las estromalisinas (-1171 5a\/6a mmp3) y el riesgo a desarrollar c\u00e1ncer de pulm\u00f3n, as\u00ed como la estimaci\u00f3n de la supervivencia de los casos ya diagnosticados, en un estudio caso-control de base hospitalaria en el que se han recogido 501 casos incidentes de c\u00e1ncer de pulm\u00f3n y 510 controles apareados por edad, g\u00e9nero y \u00e1rea de residencia. Los diferentes genotipos se han determinado por pcr-rfpl y los resultados se han analizado por regresi\u00f3n log\u00edstica. Se ha encontrado que los polimorfismos en el promotor de mmp1 y mmp13 no se asocian con el riesgo a desarrollar c\u00e1ncer de pulm\u00f3n, sin embargo parecen aumentar el tiempo de supervivencia tras el diagn\u00f3stico. Por el contrario, polimorfismos en el promotor del gen mmp2 y mmp9 parecen proteger del riesgo a desarrollar c\u00e1ncer de pulm\u00f3n y se relacionan con una mejor supervivencia. Por otro aldo, el polimorfismos en mmp3 parece asociarse con una cierta protecci\u00f3n y una mejor supervivencia en determinados grupos de estratificaci\u00f3n. En conclusi\u00f3n, nuestros resultados sugieren que los polimorfismos en el promotor del gen de las mmps pueden contribuir a la susceptibilidad ind<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismos geneticos en promotores de metaloproteasas y riesgo de cancer de pulmon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismos geneticos en promotores de metaloproteasas y riesgo de cancer de pulmon <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Gonzalez Arriaga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Adonina Tardon Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: aurora Bueno cavanillas <\/li>\n<li> Bautista garcia casas Juan (vocal)<\/li>\n<li>marina Pollan santamaria (vocal)<\/li>\n<li>nuria Malats riera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Gonzalez Arriaga El c\u00e1ncer de pulm\u00f3n representa uno de los principales problemas de salud en pa\u00edses [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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