{"id":58216,"date":"2018-03-09T22:46:02","date_gmt":"2018-03-09T22:46:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/separacion-de-enantiomeros-de-productos-farmaceuticos-a-escala-anala%c2%adtica-y-semipreparativa-mediante-cromatografa%c2%ada-de-fluidos-supercra%c2%adticos\/"},"modified":"2018-03-09T22:46:02","modified_gmt":"2018-03-09T22:46:02","slug":"separacion-de-enantiomeros-de-productos-farmaceuticos-a-escala-anala%c2%adtica-y-semipreparativa-mediante-cromatografa%c2%ada-de-fluidos-supercra%c2%adticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-cromatografico\/separacion-de-enantiomeros-de-productos-farmaceuticos-a-escala-anala%c2%adtica-y-semipreparativa-mediante-cromatografa%c2%ada-de-fluidos-supercra%c2%adticos\/","title":{"rendered":"Separaci\u00f3n de enanti\u00f3meros de productos farmac\u00e9uticos a escala anal\u00edtica y semipreparativa mediante cromatograf\u00edade fluidos supercr\u00edticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Alonso S\u00e1nchez <\/strong><\/h2>\n<p>El an\u00e1lisis y separaci\u00f3n de compuestos quierales es un \u00e1rea de inter\u00e9s crecimiento no s\u00f3lo desde un punto de vista anal\u00edtico, sino tambi\u00e9n farmacol\u00f3gico y bioqu\u00edmico. De todos es sabido que un par de enanti\u00f3meros pueden tener diferente actividad, perfiles farmacol\u00f3gicos y metabolismo. La importancia de este fen\u00f3meno ha sido reconocida por los diferentes organismos encargados de regular el desarrollo de nuevos f\u00e1rmacos, y se exige que cada enanti\u00f3mero sea estudiado de forma individualiza en los referente a sus propiedades farmacodin\u00e1micas, farmacodin\u00e9ticas y toxicol\u00f3gicas. Por lo tanto, es necesario el desarrollo de m\u00e9todos que permitan una superaci\u00f3n y evaluaci\u00f3n individualizada de cada enanti\u00f3mero. los m\u00e9todos de an\u00e1lisis m\u00e1s utilizados en al actualidad, son lso cromatogr\u00e1ficos basados en el empleo de columnas quirales. Aunque la cromatograf\u00eda l\u00edquida de alta eficacia (hplc) ha sido la t\u00e9cnica tradicionalmente empleada en las separaciones quirles, debido al amplio rango de fases estacionarias disponibles, en los \u00faltimos a\u00f1os, la cromatograf\u00eda supercr\u00edtica sfc con columnas empaquetadas, ha demostrado ser una muy buena alternativa al hplc y a la cromatograf\u00eda, de gases, logr\u00e1ndose separaciones enantiom\u00e9ricas que antes o no hab\u00edan sido posibles. las columnas usualmente empleadas en sfc quiral son las mismas columnas quirales que se comercializan para utilizar en hplc de fase normal. de entre todas ellas, cabe destacar las de derivadas de amilosa o celulosa debido al gran n\u00famero de compuestos que con ellas han sido resueltos, por lo cual tienen un campo m\u00e1s amplio de aplicaci\u00f3n. en esta tesis se estudi\u00f3 la separaci\u00f3n enantiom\u00e9rica mediante sfc de seis f\u00e1rmacos: omeprazol, lansoprazol, pantoprazol, rabeprazol, oxfendazol y cetrizina.     en este trabajo se ha realizado:     1,- estudio de la separaci\u00f3n de los compuestos mediante sfc a escala anal\u00edtica con una columna quiral derivada de polisc\u00e1ridos: chiralpak ad. Se<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Separaci\u00f3n de enanti\u00f3meros de productos farmac\u00e9uticos a escala anal\u00edtica y semipreparativa mediante cromatograf\u00edade fluidos supercr\u00edticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Separaci\u00f3n de enanti\u00f3meros de productos farmac\u00e9uticos a escala anal\u00edtica y semipreparativa mediante cromatograf\u00edade fluidos supercr\u00edticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Alonso S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/04\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Laura Toribio Recio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: marcelo Blanco romia <\/li>\n<li>alejandro Cifuentes gallego (vocal)<\/li>\n<li>Mar\u00eda  Luisa Marina alegre (vocal)<\/li>\n<li>ramon Jos\u00e9 Barrio diez caballero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Alonso S\u00e1nchez El an\u00e1lisis y separaci\u00f3n de compuestos quierales es un \u00e1rea de inter\u00e9s crecimiento no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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