{"id":58305,"date":"2007-04-05T00:00:00","date_gmt":"2007-04-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/primeras-administraciones-de-un-nuevo-antileucotrieno-en-humanos-seguridad-y-farmacocinetica-papel-del-modelado-poblacional-en-el-desarrollo-cla%c2%adnico-de-nuevos-compuestos\/"},"modified":"2007-04-05T00:00:00","modified_gmt":"2007-04-05T00:00:00","slug":"primeras-administraciones-de-un-nuevo-antileucotrieno-en-humanos-seguridad-y-farmacocinetica-papel-del-modelado-poblacional-en-el-desarrollo-cla%c2%adnico-de-nuevos-compuestos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/primeras-administraciones-de-un-nuevo-antileucotrieno-en-humanos-seguridad-y-farmacocinetica-papel-del-modelado-poblacional-en-el-desarrollo-cla%c2%adnico-de-nuevos-compuestos\/","title":{"rendered":"Primeras administraciones de un nuevo antileucotrieno en humanos: seguridad y farmacocin\u00e9tica. papel del modelado poblacional en el desarrollo cl\u00ednico de nuevos compuestos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ilonka Zsolt Fradera <\/strong><\/h2>\n<p>Sta tesis investiga el inicio del desarrollo cl\u00ednico de un nuevo inhibidor de la lipooxigeanasa, el am-24, que hab\u00eda superado la fase precl\u00ednica. Para ello se plante\u00f3 un programa inicial de desarrollo de fase i con objeto de investigar la tolerabilidad y primeras caracter\u00edsticas farmacocin\u00e9ticas y farmacodin\u00e1micas tras las primeras administraciones en humanos. Dentro de dicho programa, se dise\u00f1aron i) un primer estudio, cuyo objetivo principal era la determinaci\u00f3n  de la dosis m\u00e1xima tolerada tras dosis \u00fanica y que permitir\u00eda obtener adicionalmente los primeros datos farmacocin\u00e9ticos y farmacodin\u00e1micos en voluntarios sanos y ii) un segundo estudio que permitir\u00eda evaluar las caracter\u00edsticas farmacocin\u00e9tica y tolerabilidad del compuesto tras ser administrado a dosis repetidas. Tanto para el dise\u00f1o del estudio a dosis repetidas como para la evaluaci\u00f3n farmacocin\u00e9tica de los resultados del mismo, adicionalmente a los estudios \u00abin vivo\u00bb realizados, se han utilizado t\u00e9cnicas de modelado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Primeras administraciones de un nuevo antileucotrieno en humanos: seguridad y farmacocin\u00e9tica. papel del modelado poblacional en el desarrollo cl\u00ednico de nuevos compuestos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Primeras administraciones de un nuevo antileucotrieno en humanos: seguridad y farmacocin\u00e9tica. papel del modelado poblacional en el desarrollo cl\u00ednico de nuevos compuestos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ilonka Zsolt Fradera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel J Barbanoj Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: francesc Jan\u00e9 carrenc\u00ed\u00a0 <\/li>\n<li>Marta Valle cano (vocal)<\/li>\n<li>ignasi Gich saladich (vocal)<\/li>\n<li>erik Cobo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ilonka Zsolt Fradera Sta tesis investiga el inicio del desarrollo cl\u00ednico de un nuevo inhibidor de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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