{"id":58380,"date":"2007-09-05T00:00:00","date_gmt":"2007-09-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/evaluacion-de-la-respuesta-de-estres-agudo-en-rata-implicacion-del-receptor-serotoninergico-5-ht1a\/"},"modified":"2007-09-05T00:00:00","modified_gmt":"2007-09-05T00:00:00","slug":"evaluacion-de-la-respuesta-de-estres-agudo-en-rata-implicacion-del-receptor-serotoninergico-5-ht1a","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/malaga\/evaluacion-de-la-respuesta-de-estres-agudo-en-rata-implicacion-del-receptor-serotoninergico-5-ht1a\/","title":{"rendered":"Evaluaci\u00f3n de la respuesta de estr\u00e9s agudo en rata: implicaci\u00f3n del receptor serotonin\u00e9rgico 5-ht1a"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Rioja Villodres <\/strong><\/h2>\n<p>El objetivo del presente trabajo ha sido evaluar, en primer lugar, los efectos que ejerce el estr\u00e9s por inmovilizaci\u00f3n aguda a corto y largo plazo sobre par\u00e1metros hormonales, conductuales, actividad funcional noradren\u00e9rgica (locus coeruleus e hipocampo) y serotonin\u00e9rgica (n\u00facleos del rafe), as\u00ed como sobre varios par\u00e1metros de estr\u00e9s oxidativo perif\u00e9ricos.     en segundo lugar hemos evaluado la funci\u00f3n del receptor serotonin\u00e9rgico 5-ht 1a en estas condicones de estr\u00e9s agudo por inmovilizaci\u00f3n administrando la agonista 8-oh-dpat bien solo, bien antes de la inmovilizaci\u00f3n y el antagonista way-100635 para comprobar la especificidad del efecto que pudiera tener la administraci\u00f3n del agonista. La evaluaci\u00f3n a corto plazo se realiz\u00f3 estudiando los niveles s\u00e9ricos de corticosterona mediante ria, actividad de neuronas noradren\u00e9rgicos (y niveles hipocampales de noradrenalina mediante hplc-ed) del locus coeruleus y serotonin\u00e9rgicas de los n\u00facleos del rafe dorsal, medial, p\u00e1lido y oscuro mediante t\u00e9cnicas inmunocitoqu\u00edmicas.  por \u00faltimo se estudiaron varios marcadores plasm\u00e1ticos de estr\u00e9s oxidativo mediante t\u00e9cnicas gravim\u00e9tricas automatizadas en un analizador cobas mira s. Para estudiar los efectos del estr\u00e9s agudo a largo plazo, se emple\u00f3 el laberinto elevado en t. As\u00ed como t\u00e9cnicas inmunocitoqu\u00edmicas espec\u00edficas para evaluar la actividad de las neuronas noradren\u00e9rgicas y serotonin\u00e9rgicas. Los estudios a corto plazo confirman que existe un incremento de corticosterona en condicones de estr\u00e9s agudo.  este aumento de coricosterona se observ\u00f3 tambi\u00e9n los grupos a los que se les administr\u00f3 el 8-oh-dpat y en el grupo de animales pretratados con el way-100635, confirmando la participaci\u00f3n del receptor 5-ht 1a en la activaci\u00f3n del eje hpa.     por otro lado, la activaci\u00f3n noradren\u00e9rgica y serotonin\u00e9rgica inducida pro la inmovilizaci\u00f3n, que hemos observado en nuestro trabajo es revertida con la administraci\u00f3n del 8-oh-dpat ante<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Evaluaci\u00f3n de la respuesta de estr\u00e9s agudo en rata: implicaci\u00f3n del receptor serotonin\u00e9rgico 5-ht1a<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Evaluaci\u00f3n de la respuesta de estr\u00e9s agudo en rata: implicaci\u00f3n del receptor serotonin\u00e9rgico 5-ht1a <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Rioja Villodres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Angel Aguirre Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>Jorge Arias p\u00e9rez (vocal)<\/li>\n<li>pedro Gonz\u00e1lez santos (vocal)<\/li>\n<li>eva Tavares vazquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Rioja Villodres El objetivo del presente trabajo ha sido evaluar, en primer lugar, los efectos que 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