{"id":58387,"date":"2007-09-05T00:00:00","date_gmt":"2007-09-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-morfina-sobre-la-expresion-cerebral-de-protea%c2%adnas-relacionadas-con-el-estres-influencia-del-pretratamiento-con-yohimbina\/"},"modified":"2007-09-05T00:00:00","modified_gmt":"2007-09-05T00:00:00","slug":"efecto-de-la-morfina-sobre-la-expresion-cerebral-de-protea%c2%adnas-relacionadas-con-el-estres-influencia-del-pretratamiento-con-yohimbina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/efecto-de-la-morfina-sobre-la-expresion-cerebral-de-protea%c2%adnas-relacionadas-con-el-estres-influencia-del-pretratamiento-con-yohimbina\/","title":{"rendered":"Efecto de la morfina sobre la expresi\u00f3n cerebral de prote\u00ednas relacionadas con el estr\u00e9s. influencia del pretratamiento con yohimbina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elisa Garrido P\u00e9rez <\/strong><\/h2>\n<p>La exposici\u00f3n cr\u00f3nica a morfina origina diversos efectos no deseados tales como tolerancia, dependencia y un s\u00edndrome de abstinencia tras interrumpir su consumo. Adem\u00e1s, da lugar a distintas modificaciones celulares y moleculares, siendo el objetivo principal de la presente tesis  profundizar en el estudio de estas alteraciones derivadas del consumo cr\u00f3nico de morfina. Asimismo, el antagonista a2-adren\u00e9rgico yohimbina es capaz de bloquear algunos de los efectos de la morfina, evalu\u00e1ndose se efecto sobre las alteraciones producidas por la morfina. los resultados obtenidos en la presente tesis, muestran como la exposici\u00f3n a morfina origina en el cerebro de rata diversas alteraciones moleculares, tanto en \u00e1reas implicadas en la recompensa producida por las drogas de abuso como en regiones relacionadas con la respuesta al estr\u00e9s. Entre estas modificaciones se las encuentran inducidas en los niveles de marcadores de da\u00f1o cerebral, como pfag y nf-l, as\u00ed como en los de prote\u00ednas de defensa cerebral ante un estr\u00e9s. La capacidad de la yohimbina para limitar la aparici\u00f3n de estas alteraciones proporciona nuevas evidencias a cerca del papel beneficioso de este antagonista a2-adren\u00e9rgico en la prevenci\u00f3n del desarrollo de la dependencia opi\u00e1cea.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la morfina sobre la expresi\u00f3n cerebral de prote\u00ednas relacionadas con el estr\u00e9s. influencia del pretratamiento con yohimbina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la morfina sobre la expresi\u00f3n cerebral de prote\u00ednas relacionadas con el estr\u00e9s. influencia del pretratamiento con yohimbina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elisa Garrido P\u00e9rez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 San pablo-ceu<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Del Carmen D\u00edez  Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis fernando Alguacil merino <\/li>\n<li>Mar\u00eda Luisa Laorden carrasco (vocal)<\/li>\n<li>Mar\u00eda isabel Colado  meg\u00eda (vocal)<\/li>\n<li>Emilio Ambrosio flores (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elisa Garrido P\u00e9rez La exposici\u00f3n cr\u00f3nica a morfina origina diversos efectos no deseados tales como tolerancia, dependencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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