{"id":58397,"date":"2007-10-05T00:00:00","date_gmt":"2007-10-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/ciclo-celular-y-fisiopatologa%c2%ada-de-la-enfermedad-de-alzheimer-relevancia-de-estudios-en-celulas-extraneuronales\/"},"modified":"2007-10-05T00:00:00","modified_gmt":"2007-10-05T00:00:00","slug":"ciclo-celular-y-fisiopatologa%c2%ada-de-la-enfermedad-de-alzheimer-relevancia-de-estudios-en-celulas-extraneuronales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/ciclo-celular-y-fisiopatologa%c2%ada-de-la-enfermedad-de-alzheimer-relevancia-de-estudios-en-celulas-extraneuronales\/","title":{"rendered":"Ciclo celular y fisiopatolog\u00eda de la enfermedad de alzheimer. relevancia de estudios en c\u00e9lulas extraneuronales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00farsula Mu\u00f1oz Mor\u00f3n <\/strong><\/h2>\n<p>El objetivo de este trabajo ha sido el estudio en c\u00e9lulas extraneuronales, de alteraciones en los mecanismos de se\u00f1alizaci\u00f3n celular asociados a la patolog\u00eda de enfermedad de alzheimer (ea). Esta enfermedad, entre otras enfermedades del sistema nervioso, tiene tambi\u00e9n manifestaciones sist\u00e9micas, si bien con menores repercusiones cl\u00ednicas (nagy y cols., 2002; gibson y huang, 2002; eckert y cols., 1994). Por ello, se han utilizado tejidos perif\u00e9ricos de pacientes para el estudio de ciertos aspectos de la patolog\u00eda (li y cols., 2004; nagy y cols., 2002: oliver y cols., 2006). Trabajos recientes sugieren que tanto una expresi\u00f3n no coordinada de mol\u00e9culas del ciclo celular, como perturbaciones en los puntos de control del ciclo pueden ser uno de los mecanismos de la p\u00e9rdida neuronal postmit\u00f3tica. Debido a que las alteraciones en el ciclo celular no est\u00e1n restringidas a las neuronas en la ea se propuso el estudio de los mecanismos de control del ciclo celular en linfoblastos de enfermos de alzheimer y donantes controles de la misma edad. Los resultados presentados en esta tesis muestran, un aumento en proliferaci\u00f3n, en respuesta al suero, de linfoblastos de pacientes con ea, debido a una perturbaci\u00f3n de las interacciones moleculares entre las v\u00edas de se\u00f1alizaci\u00f3n dependientes de ca2+\/cam y pi3-k\/akt influyendo en la regulaci\u00f3n del contenido celular de p27. El hecho de que se hayan observados alteraciones similares en neuronas vulnerables del cerebro de pacientes con ea, hace que estos resultados supongan un apoyo adicional a la hip\u00f3tesis de que la ea es una enfermedad sist\u00e9mica, aportando algunas claves al estudio de la patog\u00e9nesis de la enfermedad de alzheimer y podr\u00edan eventualmente, tener inter\u00e9s para el diagnostico y la b\u00fasqueda de dianas terap\u00e9uticas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Ciclo celular y fisiopatolog\u00eda de la enfermedad de alzheimer. relevancia de estudios en c\u00e9lulas extraneuronales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Ciclo celular y fisiopatolog\u00eda de la enfermedad de alzheimer. relevancia de estudios en c\u00e9lulas extraneuronales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00farsula Mu\u00f1oz Mor\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngeles Mart\u00edn Requero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gregorio angel Santos montes <\/li>\n<li>matilde Salinas aracil (vocal)<\/li>\n<li>matilde S\u00e1nchez ayuso (vocal)<\/li>\n<li>eva Carro diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00farsula Mu\u00f1oz Mor\u00f3n El objetivo de este trabajo ha sido el estudio en c\u00e9lulas extraneuronales, de alteraciones [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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