{"id":58424,"date":"2007-11-05T00:00:00","date_gmt":"2007-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-pioglitazona-sobre-celulas-de-musculo-liso-vascular-de-ratas-y-pacientes-y-sobre-celulas-progenitoras-endoteliales-humanas-papel-del-tgf-beta-1\/"},"modified":"2007-11-05T00:00:00","modified_gmt":"2007-11-05T00:00:00","slug":"efectos-de-la-pioglitazona-sobre-celulas-de-musculo-liso-vascular-de-ratas-y-pacientes-y-sobre-celulas-progenitoras-endoteliales-humanas-papel-del-tgf-beta-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-pioglitazona-sobre-celulas-de-musculo-liso-vascular-de-ratas-y-pacientes-y-sobre-celulas-progenitoras-endoteliales-humanas-papel-del-tgf-beta-1\/","title":{"rendered":"Efectos de la pioglitazona sobre c\u00e9lulas de m\u00fasculo liso vascular de ratas y pacientes, y sobre c\u00e9lulas progenitoras endoteliales humanas: papel del tgf beta 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Santiago Redondo Blasco <\/strong><\/h2>\n<p>El tgf-beta1 ha sido considerado como una citoquina protectora frente a la arteriosclerosis. Sin embargo, el tgf-beta1 parece perder su efecto protector e incluso adquirir un papel patog\u00e9nico a lo largo de la evoluci\u00f3n cr\u00f3nica dela enfermedad cardiovascular. Nos propusimos estudiar la implicaci\u00f3n del tgf-beta1 en el efecto de la pioglitazona, un nuevo f\u00e1rmaco antidiab\u00e9tico, sobre tres modelos de c\u00e9lulas vasculares en cultivo: c\u00e9lulas de m\u00fasculo liso vascular de ratas y pacientes y c\u00e9lulas progenitoras endoteliales humanas obtenidas a partir de sangre perif\u00e9rica. Los resultados obtenidos muestran un efecto proapopt\u00f3ico de la pioglitazona, a concentraci\u00f3n de 100mcm, tanto en c\u00e9lulas de m\u00fasculo liso vascular de rata como en c\u00e9lulas de m\u00fasculo liso vascular humanas obtenidas de la arteria mamaria interna sobrante y tras la cirug\u00eda de revascularizaci\u00f3n mioc\u00e1rdica. Es destacable que este efecto se produjo tanto en las c\u00e9lulas que proven\u00edan de pacientes no diab\u00e9ticos como en las de los pacientes aquejados de diabetes tipo 2. Del mismo modo , se observ\u00f3 en todos estos modelos que el efecto apopt\u00f3tico se produc\u00eda a trav\u00e9s de la secuencia siguiente: pioglitazona, agonismo de ppargamma, secreci\u00f3n de tgf-beta1, se\u00f1alizaci\u00f3n por smad2 y apoptosis. En el modelo de c\u00e9lulas progenitoras endoteliales, sin embargo, obtenemos un efecto bif\u00e1sico inducido pro el f\u00e1rmaco: la pioglitazona induce un aumento de la adhesi\u00f3n a 1mcm y este efecto es dependiente de pparpgamma. Sin embargo, a una concentraci\u00f3n de 10mcm, la pioglitazona pierde ese efecto adhesivo, y se demuestra que la secreci\u00f3n de tgf-beta1 es un hecho determinante en la p\u00e9rdida de adhesi\u00f3n, siendo responsable del efecto bif\u00e1sico. Por todo ello, se concluye que la v\u00eda del tgf-beta1 es esencial para explicar los efectos dependientes de la concentraci\u00f3n de la pioglitazona sobre diferentes lechos vasculares en cultivo, obtenidos del animal y del humano, del vaso y de la sangre.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la pioglitazona sobre c\u00e9lulas de m\u00fasculo liso vascular de ratas y pacientes, y sobre c\u00e9lulas progenitoras endoteliales humanas: papel del tgf beta 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la pioglitazona sobre c\u00e9lulas de m\u00fasculo liso vascular de ratas y pacientes, y sobre c\u00e9lulas progenitoras endoteliales humanas: papel del tgf beta 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Santiago Redondo Blasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda   Teresa Tejerina Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: de Andr\u00e9s fernando <\/li>\n<li> Pedro de la cruz Jos\u00e9 (vocal)<\/li>\n<li>ulf Simonsen (vocal)<\/li>\n<li>carmen Montiel l\u00f3pez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Santiago Redondo Blasco El tgf-beta1 ha sido considerado como una citoquina protectora frente a la arteriosclerosis. Sin [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[957,1],"tags":[75115,129101,7195,129102,129100,24466],"class_list":["post-58424","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-sin-categoria","tag-carmen-montiel-lopez","tag-de-andres-fernando","tag-maria-teresa-tejerina-sanchez","tag-pedro-de-la-cruz-jose","tag-santiago-redondo-blasco","tag-ulf-simonsen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58424","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58424"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58424\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}