{"id":58426,"date":"2007-11-05T00:00:00","date_gmt":"2007-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-estres-oxidativo-y-del-oxido-na%c2%adtrico-en-las-alteraciones-vasculares-sistemicas-y-renales-de-la-cirrosis-biliar-experimental\/"},"modified":"2007-11-05T00:00:00","modified_gmt":"2007-11-05T00:00:00","slug":"papel-del-estres-oxidativo-y-del-oxido-na%c2%adtrico-en-las-alteraciones-vasculares-sistemicas-y-renales-de-la-cirrosis-biliar-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/papel-del-estres-oxidativo-y-del-oxido-na%c2%adtrico-en-las-alteraciones-vasculares-sistemicas-y-renales-de-la-cirrosis-biliar-experimental\/","title":{"rendered":"Papel del estr\u00e9s oxidativo y del \u00f3xido n\u00edtrico en las alteraciones vasculares, sist\u00e9micas y renales, de la cirrosis biliar experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Antonia Alcaraz Garcia <\/strong><\/h2>\n<p>Una producci\u00f3n excesiva de no es uno de los mecanismos m\u00e1s importantes causante de los cambios hemodin\u00e1micos que tienen lugar en pacientes y animales experimentales con cirrosis hep\u00e1tica. El aumento de no induce una vasodilataci\u00f3n sist\u00e9mica, debida en parte a una menor respuesta a vasoconstrictores en distintos lechos vasculares, y consecuentemente hipotensi\u00f3n arterial. La vasoconstricci\u00f3n renal ser\u00eda una consecuencia de los cambios sist\u00e9micos para retener sodio y agua y mantener as\u00ed la presi\u00f3n arterial. A pesar de esta vasoconstricci\u00f3n, la producci\u00f3n renal de no tambi\u00e9n est\u00e1 aumentada y aunque este aumento podr\u00eda ser compensatorio a la vasoconstricci\u00f3n, es interesante destacar que la inhibici\u00f3n del no en animales cirr\u00f3ticos mejora (en vez de empeorar) la perfusi\u00f3n renal y la excreci\u00f3n de sodio y agua contrario a lo que ocurre en condiciones normales. Aunque este efecto beneficioso podr\u00eda ser parcialmente debido a un aumento de la presi\u00f3n arterial, estudios realizados en este laboratorio han demostrado que dosis de inhibidores de la s\u00edntesis de no que no modifican la presi\u00f3n arterial, tambi\u00e9n aumentan la diuresis y natriuresis en los animales cirr\u00f3ticos, sugiriendo un importante efecto intrarrenal del no en la cirrosis. As\u00ed, es posible que el exceso de no en el ri\u00f1\u00f3n cirr\u00f3tico sea t\u00f3xico o est\u00e9 promoviendo parad\u00f3jicamente una vasoconstricci\u00f3n. Debido a la escasa toxicidad del no en la mayor\u00eda de los sistemas, alg\u00fan producto de la reacci\u00f3n del no debe ser el responsable de su toxicidad. en presencia de niveles elevados de ani\u00f3n super\u00f3xido (o2-) la formaci\u00f3n de peroxinitrito (onoo-) es una de las reacciones qu\u00edmicas m\u00e1s favorables del no, ya que constituye una de sus rutas de inactivaci\u00f3n. En este sentido, cada vez hay m\u00e1s evidencias de que los radicales libres derivados del ox\u00edgeno (entre los m\u00e1s importantes el o2-) est\u00e1n extraordinariamente elevados en la cirrosis y juegan un importante papel en sus manifestaciones c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del estr\u00e9s oxidativo y del \u00f3xido n\u00edtrico en las alteraciones vasculares, sist\u00e9micas y renales, de la cirrosis biliar experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del estr\u00e9s oxidativo y del \u00f3xido n\u00edtrico en las alteraciones vasculares, sist\u00e9micas y renales, de la cirrosis biliar experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Antonia Alcaraz Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Clara Ortiz Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Garc\u00eda-esta\u00f1 l\u00f3pez joaqu\u00edn Mar\u00eda <\/li>\n<li>concepcion Martinez prieto (vocal)<\/li>\n<li>alicia Rodr\u00edguez barbero (vocal)<\/li>\n<li>rodrigo D\u00edez miralles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Antonia Alcaraz Garcia Una producci\u00f3n excesiva de no es uno de los mecanismos m\u00e1s importantes causante de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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