{"id":58427,"date":"2007-11-05T00:00:00","date_gmt":"2007-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genomica-evolucion-y-redes-de-regulacion-del-plasmido-r388\/"},"modified":"2007-11-05T00:00:00","modified_gmt":"2007-11-05T00:00:00","slug":"genomica-evolucion-y-redes-de-regulacion-del-plasmido-r388","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/genomica-evolucion-y-redes-de-regulacion-del-plasmido-r388\/","title":{"rendered":"Gen\u00f3mica, evoluci\u00f3n y redes de regulaci\u00f3n del pl\u00e1smido r388"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ra\u00fal Fern\u00e1ndez L\u00f3pez <\/strong><\/h2>\n<p>Los pl\u00e1smidos conjugativos son uno de los elementos fundamentales en la transferencia gen\u00e9tica horizontal entre bacterias gram-negativas. Gracias a este proceso, genes que confiere ventajas adaptativas pueden distribuirse r\u00e1pidamente entre las poblaciones bacterianas, tal es el caso de la resistencia a antibi\u00f3ticos. R388 es el pl\u00e1smido conjugativo natural m\u00e1s peque\u00f1o caracterizado hasta la fecha y constituye un modelo experimental de referencia en el estudio de la conjugaci\u00f3n bacteriana. El objetivo del presente proyecto es estudiar a tres niveles la arquitectura gen\u00f3mica de este pl\u00e1smido:     1,- gen\u00f3mica, estudiando su organizaci\u00f3n gen\u00e9tica y los elementos conservados entre pl\u00e1smidos de su misma familia y de otras familias estudiadas.    2,- evoluci\u00f3n. Determinando cu\u00e1les son las caracter\u00edsticas fundamentales de la evoluci\u00f3n en genomas plasm\u00eddicos.     3,- regulaci\u00f3n. Estudiar la presencia de redes de regulaci\u00f3n propia y su interacci\u00f3n con el gen\u00f3ma hospedador.     la hip\u00f3tesis de partida de este proyecto es que los pl\u00e1smidos conjugativos constituyen genomas organizados, que poseen una arquitectura, una evoluci\u00f3n y unas redes de regulaci\u00f3n que le son caracter\u00edsticas, y que, aunque fuertemente dependientes del gen\u00f3ma hospedador, tienen una gran autonom\u00eda.     la metodolog\u00eda a emplear para bordar el presente proyecto se engloba en dos tipos de t\u00e9cnicas distintas:     1,- t\u00e9cnicas de biolog\u00eda molecular: secuenciaci\u00f3n del genoma, clonaci\u00f3n de promotores y de prote\u00ednas reguladoras. Determinaci\u00f3n del as unidades transcripcinales del pl\u00e1smido. Obtenci\u00f3n de perfiles de expresi\u00f3n mediante fusiones con gfp y el sistema lux. Determinaci\u00f3n de niveles de actividad de promotores mediante pcr cuantitativa. Determinaci\u00f3n del efecto de genes reguladores.     2,- t\u00e9cnicas bioinform\u00e1ticas: anotaci\u00f3n y an\u00e1lisis de la secuencia. Elaboraci\u00f3n de \u00e1rboles filogen\u00e9ticos. An\u00e1lisis de los m\u00f3dulos b\u00e1sicos de regulaci\u00f3n den el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Gen\u00f3mica, evoluci\u00f3n y redes de regulaci\u00f3n del pl\u00e1smido r388<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Gen\u00f3mica, evoluci\u00f3n y redes de regulaci\u00f3n del pl\u00e1smido r388 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ra\u00fal Fern\u00e1ndez L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando De La Cruz Calahorra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andres Moya simarro <\/li>\n<li>Juan  Fernando Poyatos adeva (vocal)<\/li>\n<li>victor De lorenzo prieto (vocal)<\/li>\n<li>alejandro Mira obrador (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ra\u00fal Fern\u00e1ndez L\u00f3pez Los pl\u00e1smidos conjugativos son uno de los elementos fundamentales en la transferencia gen\u00e9tica horizontal [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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