{"id":58492,"date":"2018-03-09T22:46:20","date_gmt":"2018-03-09T22:46:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-proteina-bcl2-mitiga-la-sobrecarga-de-calcio-mitocondrial-y-la-actividad-de-canales-l-en-celulas-pc12\/"},"modified":"2018-03-09T22:46:20","modified_gmt":"2018-03-09T22:46:20","slug":"la-proteina-bcl2-mitiga-la-sobrecarga-de-calcio-mitocondrial-y-la-actividad-de-canales-l-en-celulas-pc12","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/la-proteina-bcl2-mitiga-la-sobrecarga-de-calcio-mitocondrial-y-la-actividad-de-canales-l-en-celulas-pc12\/","title":{"rendered":"La proteina bcl2 mitiga la sobrecarga de calcio mitocondrial y la actividad de canales l en celulas pc12"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Diaz Prieto  Mar\u00eda  Natacha <\/strong><\/h2>\n<p>La muerte celular y  la supervivencia son dos procesos antag\u00f3nicos finamente regulados por los distintos miembros de una misma familia proteica, la familia bcl2, que bien promueven el progreso del proceso apopt\u00f3tico o lo frenan. Uno de los miembros m\u00e1s estudiados de esta familia es el que le da nombre, bcl2.  Bcl2 y las prote\u00ednas relacionadas se distribuyen por todos los org\u00e1nulos subcelulares, como el ret\u00edculo endopl\u00e1smico, la membrana nuclear externa y la membrana mitocondrial externa. El mecanismo de acci\u00f3n de bcl2 en el marco de la regulaci\u00f3n de la apoptosis, sin embargo, permanece sin aclarar. La compleja distribuci\u00f3n de bcl2 por los org\u00e1nulos subcelulares podr\u00eda afectar al equilibrio i\u00f3nico de las membranas, particularmente la homeostasis del  ca2+.  El ca2+ es un factor clave en la ruta apopt\u00f3tica como prueba el hecho de que la sobrecarga mitocondrial de ca2+ lleva a la apertura del poro de transici\u00f3n mitocondrial, causando la liberaci\u00f3n del citocromo c y el inicio de la cascada apopt\u00f3tica.  el hecho que bcl2 sea capaz de formar canales conductores de iones llev\u00f3 a la hip\u00f3tesis que el efecto antiapopt\u00f3tico de bcl2 podr\u00eda estar relacionado con una alteraci\u00f3n en la homeostasis del ca2+ en la mitocondria y el ret\u00edculo endopl\u00e1smico. Por ejemplo, la sobrexpresi\u00f3n de bcl2 esta asociada a alteraciones de los dep\u00f3sitos intracelulares de ca2+ por ejemplo, ret\u00edculo endopl\u00e1smico). Adem\u00e1s, la sobrexpresi\u00f3n de bcl2 tanto en clones estables de c\u00e9lulas pc12 como inducida farmacol\u00f3gicamente por galantamina en c\u00e9lulas cromafines bovinas confiere, a estas c\u00e9lulas,resistencia frente a varios est\u00edmulos apopt\u00f3ticos. dado que las c\u00e9lulas que sobrexpresan la prote\u00edna bcl2 son resistentes a est\u00edmulos apopt\u00f3ticos, estudiamos la din\u00e1mica de entrada de ca2+ y su redistribuci\u00f3n intracelular en c\u00e9lulas pc12 control y en c\u00e9lulas que sobrexpresan de forma estable la prote\u00edna bcl2 (c\u00e9lulas bcl2). Para monitorizar los cambios en la concentraci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La proteina bcl2 mitiga la sobrecarga de calcio mitocondrial y la actividad de canales l en celulas pc12<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La proteina bcl2 mitiga la sobrecarga de calcio mitocondrial y la actividad de canales l en celulas pc12 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Diaz Prieto  Mar\u00eda  Natacha <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Cano Abad Mar\u00eda  Francisca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuela Garc\u00eda l\u00f3pez <\/li>\n<li>eva al\u00e9s Gonz\u00e1lez de la higuera (vocal)<\/li>\n<li> Montero zoccola Mar\u00eda  teresa (vocal)<\/li>\n<li>Antonio Cuadrado pastor (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diaz Prieto Mar\u00eda Natacha La muerte celular y la supervivencia son dos procesos antag\u00f3nicos finamente regulados por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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