{"id":58507,"date":"2018-03-09T22:46:20","date_gmt":"2018-03-09T22:46:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetica-evolutiva-y-variabilidad-de-la-protea%c2%adna-porb-de-neisseria-meningitidis\/"},"modified":"2018-03-09T22:46:20","modified_gmt":"2018-03-09T22:46:20","slug":"genetica-evolutiva-y-variabilidad-de-la-protea%c2%adna-porb-de-neisseria-meningitidis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/genetica-evolutiva-y-variabilidad-de-la-protea%c2%adna-porb-de-neisseria-meningitidis\/","title":{"rendered":"Gen\u00e9tica evolutiva y variabilidad de la prote\u00edna porb de neisseria meningitidis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Abad Torreblanca <\/strong><\/h2>\n<p>La enfermedad meninfoc\u00f3cica es una enfermedad infecciosa de distribuci\u00f3n mundial que contin\u00faa siendo un importante problema de salud p\u00fablica, pudiendo aparecer en forma de casos espor\u00e1dicos, brotes o grandes epidemias. Esto, sumado a la gravedad de la enfermedad que evoluciona de forma severa provocando secuelas invalidantes y un elevado n\u00famero de muertes, hace que el control y la prevenci\u00f3n de esta enfermedad sean aspectos fundamentales a tener en cuenta. Para ello algo b\u00e1sico es una buena identificaci\u00f3n y caracterizaci\u00f3n de las cepas de neisseria meningitidis, agente causal de esta enfermadad. Para llevar a cabo la caracterizaci\u00f3n de estas cepas se utilizan diferentes componentes de la envuelta externa del meningococo, algunos de los cuales constituyen la base de los marcadores epidemiol\u00f3gicos empleados en su tipificaci\u00f3n. En este sentido los m\u00e1s relevantes son el polisac\u00e1rido capsular, que permite clasificar las cepas de n. Meningitidis en serogrupos, y las prote\u00ednas de membrana externa de clase 2\/3 (porb) y de clase 1 (pora), que constituyen la base del serotipado y serosubtipado, respectivamente. El serotipado y subtipado de estas cepas se realiza habitualmente mediante un enzimoinmunoensayo utilizando un panel internacional de anticuerpos monoclonales (acms). Sin embargo, un alto porcentaje de cepas, que seg\u00fan los estudios oscila entre un 20 y un 60%, resultan no tipables (nt), no subtipables (nst), o ambas cosas a la vez. Los mecanismos responsables de esta falta de reactividad con los acms est\u00e1n bien descritos en el caso de las cepas nsts para las prote\u00ednas de clase 1. La ausencia de estudios que expliquen esta falta de reactividad entre las prote\u00ednas de clase 2\/3 y los acms, junto con la ausencia de un m\u00e9todo alternativo que permite el tipado de estas cepas, es lo que ha llevado al planteamiento inicial de esta tesis cuyo primer objetivo ha sido: analizar los posibles mecanismos responsables del car\u00e1cter nt de las cepas de n. Meningiti<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Gen\u00e9tica evolutiva y variabilidad de la prote\u00edna porb de neisseria meningitidis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Gen\u00e9tica evolutiva y variabilidad de la prote\u00edna porb de neisseria meningitidis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Abad Torreblanca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Julio A. V\u00e1zquez Moreno<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julian Perera gonzalez <\/li>\n<li>pere Coll figa (vocal)<\/li>\n<li> S\u00e1ez nieto Juan  Antonio (vocal)<\/li>\n<li>\u00c1lvaro Pascual hern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Abad Torreblanca La enfermedad meninfoc\u00f3cica es una enfermedad infecciosa de distribuci\u00f3n mundial que contin\u00faa siendo un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[56335,7259,21267,20133,129290,5724],"class_list":["post-58507","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-alvaro-pascual-hernandez","tag-julian-perera-gonzalez","tag-julio-a-vazquez-moreno","tag-pere-coll-figa","tag-raquel-abad-torreblanca","tag-saez-nieto-juan-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58507"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58507\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58507"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58507"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}