{"id":58528,"date":"2018-03-09T22:46:23","date_gmt":"2018-03-09T22:46:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sa%c2%adntesis-y-caracterizacion-de-nuevos-complejos-de-paladioii-y-platinoii-con-nucleobases-modelo-y-ligandos-relacionados-estudio-de-la-interaccion-con-el-dna-y-actividad-citotoxica\/"},"modified":"2018-03-09T22:46:23","modified_gmt":"2018-03-09T22:46:23","slug":"sa%c2%adntesis-y-caracterizacion-de-nuevos-complejos-de-paladioii-y-platinoii-con-nucleobases-modelo-y-ligandos-relacionados-estudio-de-la-interaccion-con-el-dna-y-actividad-citotoxica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-organometalicos\/sa%c2%adntesis-y-caracterizacion-de-nuevos-complejos-de-paladioii-y-platinoii-con-nucleobases-modelo-y-ligandos-relacionados-estudio-de-la-interaccion-con-el-dna-y-actividad-citotoxica\/","title":{"rendered":"S\u00edntesis y caracterizaci\u00f3n de nuevos complejos de paladio(ii) y platino(ii) con nucleobases modelo y ligandos relacionados. estudio de la interacci\u00f3n con el dna y actividad citot\u00f3xica"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Villa Bolar\u00edn Mar\u00eda Dolores <\/strong><\/h2>\n<p>Se ha realizado la s\u00edntesis, caracterizaci\u00f3n (mediante determinaciones anal\u00edticas, espectrosc\u00f3picas y difracci\u00f3n de rayos x), as\u00ed como el estudio de interacci\u00f3n con el dna (por dicro\u00edsmo circular, electroforesis en gel de agarosa y microscop\u00eda de fuerzas at\u00f3micas) de nuevos complejos organomet\u00e1licos antitumorales de paladio(ii) y platino(ii) con ligandos nucleobases modelo, tales como metilcitosina, metiltimina, metiluracilo, alquilguaninas y metilhipoxantina, y ligandos triazolopirimidinas. En busca de ligandos que sean capaces de transportar la metalodroga m\u00e1s espec\u00edficamente a la c\u00e9lula cancer\u00edgena, se han utilizado, adem\u00e1s, esteroides derivados de la testosterona. Tambi\u00e9n se han realizado ensayos citot\u00f3xicos de los nuevos complejos organomet\u00e1licos de platino(ii) en las l\u00edneas celulares hl60 (leucemia humana) y t47d (c\u00e1ncer de mama).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>S\u00edntesis y caracterizaci\u00f3n de nuevos complejos de paladio(ii) y platino(ii) con nucleobases modelo y ligandos relacionados. estudio de la interacci\u00f3n con el dna y actividad citot\u00f3xica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 S\u00edntesis y caracterizaci\u00f3n de nuevos complejos de paladio(ii) y platino(ii) con nucleobases modelo y ligandos relacionados. estudio de la interacci\u00f3n con el dna y actividad citot\u00f3xica <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Villa Bolar\u00edn Mar\u00eda Dolores <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ruiz L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: virtudes Moreno Martinez <\/li>\n<li>j. Evans david (vocal)<\/li>\n<li> Bastida de la calle rufina (vocal)<\/li>\n<li>christoph Janiak (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Villa Bolar\u00edn Mar\u00eda Dolores Se ha realizado la s\u00edntesis, caracterizaci\u00f3n (mediante determinaciones anal\u00edticas, espectrosc\u00f3picas y difracci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[863,8235],"tags":[101453,129336,129335,129334,129333,3037],"class_list":["post-58528","post","type-post","status-publish","format-standard","hentry","category-compuestos-organometalicos","category-murcia","tag-bastida-de-la-calle-rufina","tag-christoph-janiak","tag-j-evans-david","tag-jose-ruiz-lopez","tag-villa-bolarin-maria-dolores","tag-virtudes-moreno-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58528"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58528\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58528"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58528"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}