{"id":58554,"date":"2018-03-09T22:46:23","date_gmt":"2018-03-09T22:46:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/organizacion-de-la-red-epitelial-ta%c2%admica-en-ratones-deficientes-en-los-receptores-eph-b2-y-o-eph-b3\/"},"modified":"2018-03-09T22:46:23","modified_gmt":"2018-03-09T22:46:23","slug":"organizacion-de-la-red-epitelial-ta%c2%admica-en-ratones-deficientes-en-los-receptores-eph-b2-y-o-eph-b3","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/organizacion-de-la-red-epitelial-ta%c2%admica-en-ratones-deficientes-en-los-receptores-eph-b2-y-o-eph-b3\/","title":{"rendered":"Organizaci\u00f3n de la red epitelial t\u00edmica en ratones deficientes en los receptores eph b2 y\/o eph b3"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garc\u00eda-ceca Hern\u00e1ndez Jos\u00e9 Javier <\/strong><\/h2>\n<p>En el presente trabajo de tesis doctoral se produndiza en el papel de los receptores eph b2 y eph b3 en la organizaci\u00f3n y funci\u00f3n t\u00edmica, con especial \u00e9nfasis en el componente epitelial, utilizando para ello ratones deficientes en eph b2 y\/o eph b3. En primer lugar, hemos determinado que estas mol\u00e9culas, junto con sus ligandos, las ephrinas b1 y b2, se expresan en todas las subpoblaciones de timocitos y en el componente epitelial del estroma t\u00edmico. Adem\u00e1s, la ausencia de estas nol\u00e9culas no modifica la expresi\u00f3n de sus ligandos, ni la del otro receptor no mutado, as\u00ed como la expresi\u00f3n de otras mol\u00e9culas necesarias para la funcionalidad de las c\u00e9lulas epiteliales. Por otro lado, la ausencia de las eph b2 y\/o eph b3 resulta en timos peque\u00f1os, hipocelulares, donde las subpoblaciones epiteliales y linfoides muestran menor tasa proliferativa y un incremento de c\u00e9lulas apopt\u00f3ticas. Pero, a pesar de su baja celularidad, los timos mutantes no muestran variaciones importantes en las proporciones de las distintas subpoblaciones de timocitos, salvo un cierto bloqueo temprano, con disminuci\u00f3n significativa desde el estadio dn3. Sin embargo, los timos deficientes en eph b2 y\/o eph b3 sufren profundas alteraciones en el epitelio t\u00edmico, en general comunes a los tres fenotipos estudiados, pero con suficientes aspectos espec\u00edficos en cada uno de ellos para indicar que el papel de estas mol\u00e9culas en el timo no es solapante sino espec\u00edfico, de manera que la ausencia de un receptor no es suplida por la presencia del otro. Aun as\u00ed, parece existir un cierto grado de cooperaci\u00f3n entre ellas, ya que la falta de ambas mol\u00e9culas induce la aparici\u00f3n de un fenotipo m\u00e1s severo. No obstante, las mol\u00e9culas eph b2 y\/o eph b3 no parecen ser imprescindibles para la organog\u00e9nesis temprana del timo (11.5f). Pero, a partir de 13.5f comienzan a aparecer, en los \u00faltimos mutantes, todas las caracter\u00edsticas apreciadas en el estadio adulto, que gradualmente y especialmente, a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Organizaci\u00f3n de la red epitelial t\u00edmica en ratones deficientes en los receptores eph b2 y\/o eph b3<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Organizaci\u00f3n de la red epitelial t\u00edmica en ratones deficientes en los receptores eph b2 y\/o eph b3 <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garc\u00eda-ceca Hern\u00e1ndez Jos\u00e9 Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agustin Gregorio Zapata Gonzalez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Torroba cabeza de vaca Marta <\/li>\n<li>isabel Fari\u00f1as g\u00f3mez (vocal)<\/li>\n<li>joaqu\u00edn Teixid\u00f3 calvo (vocal)<\/li>\n<li> Razquin peralta blanca esther (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garc\u00eda-ceca Hern\u00e1ndez Jos\u00e9 Javier En el presente trabajo de tesis doctoral se produndiza en el papel de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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