{"id":58577,"date":"2018-03-09T22:46:23","date_gmt":"2018-03-09T22:46:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelado-matematico-y-simulacion-espectral-de-enfermedades-geneticas-en-el-corazon-humano\/"},"modified":"2018-03-09T22:46:23","modified_gmt":"2018-03-09T22:46:23","slug":"modelado-matematico-y-simulacion-espectral-de-enfermedades-geneticas-en-el-corazon-humano","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/resolucion-de-ecuaciones-diferenciales-ordinarias\/modelado-matematico-y-simulacion-espectral-de-enfermedades-geneticas-en-el-corazon-humano\/","title":{"rendered":"Modelado matem\u00e1tico y simulaci\u00f3n espectral de enfermedades gen\u00e9ticas en el coraz\u00f3n humano"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alfonso Bueno Orovio <\/strong><\/h2>\n<p>Los objetivos de la presente tesis pueden ser resumidos en tres categor\u00edas principales:     1,- la creaci\u00f3n de un nuevo modelo celular, computacionalmente eficiente por lo suficientemente flexible como para reproducir con precisi\u00f3n las propiedades el\u00e9ctricas de lso miocitos del coraz\u00f3n, tanto en condicones sanas como patol\u00f3gicas.     2,- el desarrollo e implementaci\u00f3n de m\u00e9todos computaciones de orden elevado (m\u00e9todos espectrales) para la simulaci\u00f3n de la actividad el\u00e9ctrica del coraz\u00f3n, incorporando a este tipo de m\u00e9todos la geometr\u00eda irregular del m\u00fasculo cardiaco.     3,- aplicaciones electrofisiol\u00f3gicas pr\u00e1cticas, como el modelado y caracterizaci\u00f3n de enfermedades gen\u00e9ticas capaces de producir muerte cardiaca repentina.     en la primera parte dela tesis, centrada en el modelado matem\u00e1tico en electrofisiolog\u00eda, se presenta un nuevo modelo m\u00ednimo capaz de reproducir con exactitud las propiedades el\u00e9ctricas del os ventr\u00edculos humano, as\u00ed como una comparaci\u00f3n exhaustiva de los distintos modelos matem\u00e1ticos existentes para tal fin. Una vez validado, el modelo matem\u00e1tico es empleado para caracterizar el s\u00edndrome de brugada, enfermedad gen\u00e9tica asociada a disfunciones por mutaci\u00f3n de los canales de sodio en el coraz\u00f3n y humano y responsable entre el 4 y el 12% del total de muertes s\u00fabitas en humanos.     la segunda parte de la tesis abarca la aplicaci\u00f3n de m\u00e9todos espectrales en el campo de la electrofisiolog\u00eda computaciones, as\u00ed como la extensi\u00f3n de este tipo de m\u00e9todos num\u00e9ricos a problemas caracterizados por su definici\u00f3n en dominios irregulares, como la geometr\u00eda inherente al m\u00fasculo cardiaco.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelado matem\u00e1tico y simulaci\u00f3n espectral de enfermedades gen\u00e9ticas en el coraz\u00f3n humano<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelado matem\u00e1tico y simulaci\u00f3n espectral de enfermedades gen\u00e9ticas en el coraz\u00f3n humano <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alfonso Bueno Orovio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Castilla-la mancha<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> P\u00e9rez Garc\u00eda V\u00edctor Manuel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Soler vizca\u00edno <\/li>\n<li>henar Herrero sanz (vocal)<\/li>\n<li>Carlos V\u00e1zquez cent\u00f3n (vocal)<\/li>\n<li> Ferrero y de loma-osorio Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alfonso Bueno Orovio Los objetivos de la presente tesis pueden ser resumidos en tres categor\u00edas principales: 1,- [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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