{"id":58615,"date":"2018-03-09T22:46:27","date_gmt":"2018-03-09T22:46:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-de-las-protea%c2%adnas-de-division-celular-ftsz-y-zipa-de-escherichia-coli-caracterizacion-bioqua%c2%admica-biofa%c2%adsica-y-estructural\/"},"modified":"2018-03-09T22:46:27","modified_gmt":"2018-03-09T22:46:27","slug":"interaccion-de-las-protea%c2%adnas-de-division-celular-ftsz-y-zipa-de-escherichia-coli-caracterizacion-bioqua%c2%admica-biofa%c2%adsica-y-estructural","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-de-las-protea%c2%adnas-de-division-celular-ftsz-y-zipa-de-escherichia-coli-caracterizacion-bioqua%c2%admica-biofa%c2%adsica-y-estructural\/","title":{"rendered":"Interacci\u00f3n de las prote\u00ednas de divisi\u00f3n celular ftsz y zipa de escherichia coli: caracterizaci\u00f3n bioqu\u00edmica, biof\u00edsica y estructural"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  L\u00f3pez Navajas Mar\u00eda Pilar <\/strong><\/h2>\n<p>La prote\u00edna ftsz es una gtpasa hom\u00f3loga en bacterias de la tubulina que juega un papel central en la divisi\u00f3n celular bacteriana mediante la formaci\u00f3n de un anillo din\u00e1mico en el sitio de divisi\u00f3n. En el caso de e. Coli, ftsz-gdp forma olig\u00f3meros en disoluci\u00f3n mediante un proceso no corporativo ligado al magnesio. En presencia de gtp, ftsz polimeriza de forma cooperativa para formar una variedad de pol\u00edmeros (filamentos finos, anchos, c\u00edrculos, cintas), dependiendo de las condiciones de la disoluci\u00f3n, por medio de mecanismos no bien comprendidos. Existen evidencias experimentales que apuntan a que el proceso de ensamblaje de las distintas prote\u00ednas de la maquinaria de divisi\u00f3n celular bacteriana para formar el din\u00e1mico anillo septal ocurre de manera concertada y no lineal. El primero de los complejos multiproteicos que se forma en el proto-anillo que en e. Coli est\u00e1 constituido por tres prote\u00ednas (ftsz. Ftsa y zipa) cuyo ensamblaje en la membrana citopl\u00e1smica se requiere para la posterior incorporaci\u00f3n del resto de las prote\u00ednas de divisi\u00f3n del anillo maduro. La informaci\u00f3n que se tiene sobre las interacciones entre estas prote\u00ednas del proto-anillo provienen esencialmente de estudios gen\u00e9ticos y se desconocen los par\u00e1metros de equilibrio y cin\u00e9ticos que gobiernan estas interacciones, as\u00ed como la organizaci\u00f3n estructural de este complejo. Con objeto de definir los par\u00e1metros cuantitativos y la organizaci\u00f3n estructural de las interacciones que dan lugar a la formaci\u00f3n de complejos del proto-anillo bacteriano, en esta tesis doctoral, se han caracterizado los complejos de ftsz y zipa de e. Coli y los efectos de esta interacci\u00f3n sobre el ensamblaje de ftsz. Se han empleado dos formas de zipa (con cola de histidinas), una conteniendo la secuencia \u00edntegra de zipa (la cual puede estar soluble en detergente o sin detergente) y la otra conteniendo el dominio globular citoplasm\u00e1tico (careciendo del segmento de transmembrana n-terminal) que es e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interacci\u00f3n de las prote\u00ednas de divisi\u00f3n celular ftsz y zipa de escherichia coli: caracterizaci\u00f3n bioqu\u00edmica, biof\u00edsica y estructural<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interacci\u00f3n de las prote\u00ednas de divisi\u00f3n celular ftsz y zipa de escherichia coli: caracterizaci\u00f3n bioqu\u00edmica, biof\u00edsica y estructural <\/li>\n<li><strong>Autor:<\/strong>\u00a0  L\u00f3pez Navajas Mar\u00eda Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Germ\u00e1n Rivas Caballero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Porras Gallo Mar\u00eda Almudena <\/li>\n<li>Jes\u00fas Mingorance Ruiz (vocal)<\/li>\n<li>Miguel Vicente Mu\u00f1oz (vocal)<\/li>\n<li>Jes\u00fas Perez Gil (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de L\u00f3pez Navajas Mar\u00eda Pilar La prote\u00edna ftsz es una gtpasa hom\u00f3loga en bacterias de la tubulina que [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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