{"id":58675,"date":"2018-03-09T22:46:31","date_gmt":"2018-03-09T22:46:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-neoangiogenesis-y-expresion-genica-diferencial-en-pacientes-con-cancer-de-pulmon\/"},"modified":"2018-03-09T22:46:31","modified_gmt":"2018-03-09T22:46:31","slug":"estudio-de-neoangiogenesis-y-expresion-genica-diferencial-en-pacientes-con-cancer-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/estudio-de-neoangiogenesis-y-expresion-genica-diferencial-en-pacientes-con-cancer-de-pulmon\/","title":{"rendered":"Estudio de neoangiog\u00e9nesis y expresi\u00f3n g\u00e9nica diferencial en pacientes con c\u00e1ncer de pulm\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Carrillo De Santa Pau Enrique <\/strong><\/h2>\n<p>Actualmente, el c\u00e1ncer de pulm\u00f3n es la primera causa de muerte por c\u00e1ncer en el mundo, con una supervivencia menor del 15% al cabo de cinco a\u00f1os de detectarse e iniciares el tratamiento. Esta baja supervivencia se be a procesos metast\u00e1sicos tempranos, que ocurren en los estadios precoces del desarrollo tumoral, paralos que no disponemos de medios  eficaces para su detecci\u00f3n. Esto determina la necesidad no s\u00f3lo de desarrollar nuevas estrategias preventivas y terap\u00e9uticas, siendo de hallar factores pron\u00f3sticos fiables en las etapas iniciales de la g\u00e9nesis tumoral. En este sentido, la identificaci\u00f3n de marcadores moleculares fiables que indiquen la probabilidad de desarrollo de un tumor y el potencial invasivo y metast\u00e1tico en sus fases iniciales de desarrollo, es un paso imprescindible en la lucha contra el c\u00e1ncer de pulm\u00f3n. Hoy conocemos que los fen\u00f3menos de progresi\u00f3n tumor a, invasi\u00f3n y met\u00e1stasis que conducen a la malignizaci\u00f3n neopl\u00e1sica van de depender del proceso de neonangiog\u00e9neis. En este trabajo se aplican, en muestras cl\u00ednicas, t\u00e9cnicas de biolog\u00eda celular y molecular para el estudio de la neoangig\u00e9nsis y la b\u00fasqueda de marcadores diagn\u00f3sticos. para ello se realizan un estudio con inmunhostoqu\u00edmica en tejido y elisa en sangre, de los factores y receptores de la familia del vegf, el factor angiog\u00e9nico m\u00e1s potente conocido hasta la fecha. Las diferencias encontradas entre distintos par\u00e1metros cl\u00ednicos de los pacientes estudiados, seg\u00fan la expresi\u00f3n de los distintos vegfs y vegfrs en tejido y los niveles de vegf-a en el suero, podr\u00edan permitir una mejor estratificaci\u00f3n de los tumores y a orientar en la elecci\u00f3n de la mejor opci\u00f3n de tratamiento. Finalmente, se aplican t\u00e9cnicas de an\u00e1lisis m\u00faltiples de expresi\u00f3n g\u00e9nica diferencial en muestras cl\u00ednicas de pacientes diagnosticados de adenocarcinoma de pulm\u00f3n, con objeto de identificar genes candidatos a marcadores diagn\u00f3sticos. En este sentido, el an\u00e1lisis de muestr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de neoangiog\u00e9nesis y expresi\u00f3n g\u00e9nica diferencial en pacientes con c\u00e1ncer de pulm\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de neoangiog\u00e9nesis y expresi\u00f3n g\u00e9nica diferencial en pacientes con c\u00e1ncer de pulm\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Carrillo De Santa Pau Enrique <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Enrique Caso Pel\u00e1ez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Iniesta serrano Mar\u00eda pilar <\/li>\n<li>julio Ancochea berm\u00fadez (vocal)<\/li>\n<li>ricardo Paniagua g\u00f3mez-\u00e1lvarez (vocal)<\/li>\n<li>florentino Fern\u00e1ndez riverola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carrillo De Santa Pau Enrique Actualmente, el c\u00e1ncer de pulm\u00f3n es la primera causa de muerte por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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