{"id":58729,"date":"2018-03-09T22:46:34","date_gmt":"2018-03-09T22:46:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-sa%c2%adntesis-de-peptidos-para-el-diagnostico-de-la-infeccion-por-el-virus-de-la-hepatitis-g-gbv-c-hgv\/"},"modified":"2018-03-09T22:46:34","modified_gmt":"2018-03-09T22:46:34","slug":"diseno-y-sa%c2%adntesis-de-peptidos-para-el-diagnostico-de-la-infeccion-por-el-virus-de-la-hepatitis-g-gbv-c-hgv","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/diseno-y-sa%c2%adntesis-de-peptidos-para-el-diagnostico-de-la-infeccion-por-el-virus-de-la-hepatitis-g-gbv-c-hgv\/","title":{"rendered":"Dise\u00f1o y s\u00edntesis de p\u00e9ptidos para el diagn\u00f3stico de la infecci\u00f3n por el virus de la hepatitis g (gbv-c\/hgv)"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  P\u00e9rez Escoda M. Teresa <\/strong><\/h2>\n<p>La preValencia del virus de la hepatitis g (gbv-c\/hgv) oscila entre el 1 y el 4% en la poblaci\u00f3n general. Sin embargo este porcentaje aumenta hasta el 20-30% en los individuos expuestos a sangre o sus derivados, en individuos infectados por el virus de la hepatitis c o por el virus de la inmunodeficiencia humana (hiv), hecho que indica que se transmite principalmente por v\u00eda parenteral. Aunque no est\u00e1 claro su potencial patog\u00e9nico, los estudios m\u00e1s recientes sugieren que la infecci\u00f3n por este virus reduce la mortalidad en lso pacientes infectados por el hiv, de ah\u00ed el inter\u00e9s en disponer de una herramienta que permita el diagn\u00f3stico de la infecci\u00f3n por gbv-c\/hgv de un modo r\u00e1pido y sencillo.     desde hace a\u00f1os, los p\u00e9ptidos sint\u00e9ticos se vienen utilizando en sistemas de diagn\u00f3stico para muchas enfermedades, sin embargo, los p\u00e9ptidos lineales que mimetizan ep\u00edtopos b son d\u00e9bilmente reconocidos por lso anticuerpos, y por ello, existe la tendencia de utilizar combinaciones m\u00e1s complejas que permitan mejorar tanto la sensibilidad como la especificidad de los ensayos.     en esta tesis se han dise\u00f1ado y sintetizado, utilizando la metodolog\u00eda de s\u00edntesis en fase s\u00f3lida, construcciones pept\u00eddicas en las que se combinan regiones de prote\u00ednas de envoltura y no estructurales. Se han sintetizado tnato p\u00e9ptidos quim\u00e9ricos, que contienen m\u00e1s de un ep\u00edtopo (lineales y ramificados), como p\u00e9ptidos c\u00edclicos en lso que los ep\u00edtopos sufren restricci\u00f3n de movilidad.     la capacidad antig\u00e9nica de las construcciones sint\u00e9ticas se ha evaluado utilizando principalmente la t\u00e9cnica del enzimoinmunoensayo (elisa) aunque tambi\u00e9n se ha investigado la utilidad de la t\u00e9cnica de la resonancia del plasman de superficie (spr) para detectar la presencia de anticuerpos anti gbv-c\/hgv en muestras de suero de individuos pertenecientes tanto a los grupos de riesgo como en la poblaci\u00f3n sana. Adem\u00e1s, se ha realizado un estuido conformacional con la finalidad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y s\u00edntesis de p\u00e9ptidos para el diagn\u00f3stico de la infecci\u00f3n por el virus de la hepatitis g (gbv-c\/hgv)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y s\u00edntesis de p\u00e9ptidos para el diagn\u00f3stico de la infecci\u00f3n por el virus de la hepatitis g (gbv-c\/hgv) <\/li>\n<li><strong>Autor:<\/strong>\u00a0  P\u00e9rez Escoda M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Haro Villar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Asuncion Alsina Esteller <\/li>\n<li>Eva Mart\u00ednez C\u00e1cerez (vocal)<\/li>\n<li>Gemma Fabri\u00ed\u00a0s Domingo (vocal)<\/li>\n<li>Roger Galve (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de P\u00e9rez Escoda M. Teresa La preValencia del virus de la hepatitis g (gbv-c\/hgv) oscila entre el 1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,969],"tags":[129795,129796,49965,11947,129794,129797],"class_list":["post-58729","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-peptidos","tag-eva-Martinez-cacerez","tag-gemma-fabrii-s-domingo","tag-isabel-haro-villar","tag-maria-asuncion-alsina-esteller","tag-perez-escoda-m-teresa","tag-roger-galve"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58729"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58729\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}