{"id":58735,"date":"2018-03-09T22:46:34","date_gmt":"2018-03-09T22:46:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-de-la-presenilina-1-com-a-inhibidor-transcripcional-de-la-beta-catenina\/"},"modified":"2018-03-09T22:46:34","modified_gmt":"2018-03-09T22:46:34","slug":"estudi-de-la-presenilina-1-com-a-inhibidor-transcripcional-de-la-beta-catenina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudi-de-la-presenilina-1-com-a-inhibidor-transcripcional-de-la-beta-catenina\/","title":{"rendered":"Estudi de la presenilina 1 com a inhibidor transcripcional de la beta-catenina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Inma Raurell Saborit <\/strong><\/h2>\n<p>La enfermedad de alzheimer es la patolog\u00eda neurodegenerativa m\u00e1s habitual en el mundo occidental. Mutaciones en el gen de la presenilina l son responsables de la aparici\u00f3n de un tipo de enfermedad de alzheimer heredable, caracterizada por aparecer a edades tempranas. La presenilina 1, presente en muchos tejidos adem\u00e1s de en cerebro, es una prote\u00edna transmembrana que se endoproteoliza generando un fragmento amino y otro carboxiterminal. Se ha descrito que la presenilina 1 es un modulador negativo de la actividad de tcf-4 beta-catenina. el efecto inhibidor de la ps1 correctamente procesada sobre la actividad transcripcional de complejo tcf-4 beta-catenina es dependiente de la actividad gamma-secretasa. Esta inhibici\u00f3n es debida a la generaci\u00f3n de un fragmento que corresponde al dominio citos\u00f3lico de la e-cadherina. Este fragmento se genera por acci\u00f3n de la actividad gamma-secretasa de la ps1 sobre la e-cadherina entera. El fragmento citos\u00f3lico de e-cadherina interacciona con la beta-catenina, pero no impide que esta \u00faltima proteina pueda trastocar al n\u00facleo, ni tampoco modifica la interacci\u00f3n entre la beta-catenina y el tcf-4. Nuestros resultados indican que el mecanismo inhibidor podr\u00eda ser debido a un aumento de la degradaci\u00f3n del factor de transcripci\u00f3n cbp promovida por el fragmento citos\u00f3lico de e-cadherina. Mutaciones espec\u00edficas en el gen de la ps1, presentes en algunos casos de alzheimer familiar precoz, impiden que la ps1 se procese correctamente. El efecto inhibidor de la forma no procesada de la ps1 sobre la actividad del complejo tcf-4 beta-catenina, es diferente del efecto causado por la forma de la ps1 que si se procesa. La inhibici\u00f3n de la actividad transcripcional es en este caso independiente tanto de la actividad gamma-secretasa de la ps1 como de la interacci\u00f3n directa con la beta-catenina. La ps1 no procesada interacciona con la placoglobina con una afinidad similar a la beta-catenina, pero la interacci\u00f3n no est\u00e1 mediada por los mismos residuos en las dos cateninas. Adem\u00e1s, la ps1 no procesada cuando esta asociada a placoglobina, aumenta la interacci\u00f3n entre esta prote\u00edna y el tcf-4 impidiendo que este factor transcripcional se una al dna.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi de la presenilina 1 com a inhibidor transcripcional de la beta-catenina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi de la presenilina 1 com a inhibidor transcripcional de la beta-catenina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Inma Raurell Saborit <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mireia Du\u00f1ach MasJuan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan xavier Comella carnice <\/li>\n<li>Francisco j. Mu\u00f1oz lopez (vocal)<\/li>\n<li>Elena Sancho (vocal)<\/li>\n<li>Elena Galea rodriguez de velasco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Inma Raurell Saborit La enfermedad de alzheimer es la patolog\u00eda neurodegenerativa m\u00e1s habitual en el mundo occidental. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[129806,129805,129804,129803,41179,66956],"class_list":["post-58735","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-elena-galea-rodriguez-de-velasco","tag-elena-sancho","tag-francisco-j-munoz-lopez","tag-inma-raurell-saborit","tag-joan-xavier-comella-carnice","tag-mireia-dunach-masjuan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58735"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58735\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}