{"id":58751,"date":"2018-03-09T22:46:34","date_gmt":"2018-03-09T22:46:34","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-pronostica-de-la-va%c2%ada-de-los-genes-reparadores-en-cancer-de-colon-esporadico\/"},"modified":"2018-03-09T22:46:34","modified_gmt":"2018-03-09T22:46:34","slug":"implicacion-pronostica-de-la-va%c2%ada-de-los-genes-reparadores-en-cancer-de-colon-esporadico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/implicacion-pronostica-de-la-va%c2%ada-de-los-genes-reparadores-en-cancer-de-colon-esporadico\/","title":{"rendered":"Implicaci\u00f3n pron\u00f3stica de la v\u00edade los genes reparadores en c\u00e1ncer de colon espor\u00e1dico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Vidaurreta L\u00e1zaro <\/strong><\/h2>\n<p>El c\u00e1ncer colorrectal se desarrolla en el 10-15% de los casos a trav\u00e9s de la v\u00eda gen\u00e9tica de la inestabilidad de microsat\u00e9lites (msi) debida a una alteraci\u00f3n en los genes reparadores del dna. El objetivo de este trabajo ha sido el an\u00e1lisis de la msi, el estudio de la metilaci\u00f3n del promotor del gen hmlh1 y su implicaci\u00f3n pron\u00f3stica. La poblaci\u00f3n objeto de estudio han sido 350 pacientes diagnosticados de carcinoma colorrectal espor\u00e1dico en el hospital universitario cl\u00ednico san carlos. Se realiz\u00f3 la determinaci\u00f3n de msi de acuerdo con el consenso del nci mediante pcr y an\u00e1lisis de las secuencias. La metilaci\u00f3n del gen hmlh1 se realiz\u00f3 en aquellos pacientes que presentaron msi mediante modificaci\u00f3n del adn con bisulfito y confirmaci\u00f3n de la metilaci\u00f3n por amplificaci\u00f3n con primers espec\u00edficos.  el 15.5% de los carcinomas colorrectales espor\u00e1dicos estudiados se desarrollaron por la v\u00eda de la msi; de ellos el 6.9% presentaron msi-h y el 8.6% msi-l. El 66.6% de los tumores msi-h presentaron metilaci\u00f3n total. Los factores con valor pron\u00f3stico independiente en la supervivencia global de los pacientes con carcinoma colorrectal fueron el estadio tumoral y la msi. Los pacientes que presentaron msi-h ten\u00edan un 67% de reducci\u00f3n de la tasa de fallecer. Los tumores con alta msi se caracterizan por presentar mejor pron\u00f3stico.  palabras clave: metilaci\u00f3n hmlh1, msi, c\u00e1ncer colorrectal, pron\u00f3stico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaci\u00f3n pron\u00f3stica de la v\u00edade los genes reparadores en c\u00e1ncer de colon espor\u00e1dico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaci\u00f3n pron\u00f3stica de la v\u00edade los genes reparadores en c\u00e1ncer de colon espor\u00e1dico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Vidaurreta L\u00e1zaro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/05\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio  Jose Torres Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  Jose Torres Garc\u00eda <\/li>\n<li> Turnay Abad Francisco J. (vocal)<\/li>\n<li>Antonio Ballesta Gimeno (vocal)<\/li>\n<li>Damian Garc\u00eda Olmo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Vidaurreta L\u00e1zaro El c\u00e1ncer colorrectal se desarrolla en el 10-15% de los casos a trav\u00e9s de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160],"tags":[19865,15009,19295,129832,129833],"class_list":["post-58751","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","tag-antonio-ballesta-gimeno","tag-antonio-jose-torres-garcia","tag-damian-garcia-olmo","tag-marta-vidaurreta-lazaro","tag-turnay-abad-francisco-j"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58751","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58751"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58751\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58751"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58751"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}