{"id":58780,"date":"2007-01-06T00:00:00","date_gmt":"2007-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/comportamiento-y-regulacion-de-los-telometos-en-la-carcinogenesis-colorectal\/"},"modified":"2007-01-06T00:00:00","modified_gmt":"2007-01-06T00:00:00","slug":"comportamiento-y-regulacion-de-los-telometos-en-la-carcinogenesis-colorectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia-clinica\/comportamiento-y-regulacion-de-los-telometos-en-la-carcinogenesis-colorectal\/","title":{"rendered":"Comportamiento y regulaci\u00f3n de los telometos en la carcinogenesis colorectal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Valls Bautista <\/strong><\/h2>\n<p>La neoplasia colorrectal ocupa el segundo lugar entre las m\u00e1s frecuentes y tambi\u00e9n es la segunda que causa m\u00e1s muertes. Aunque, en los \u00faltimos a\u00f1os las mejoras en los tratamientos quir\u00fargicos, neoadyuvantes y adyuvantes han construido al aumento de la supervivencia y al porcentaje de curaciones. Por otra parte, se contin\u00faan usando los mismos factores pron\u00f3sticos que hace unos a\u00f1os, variables anatomopatol\u00f3gicas del tumor. El hecho de que la carcinog\u00e9nesis, colorrectal sea una de la mejor estudiadas permite que los genes o factores que se ven alterados durante este proceso puedan ser estudiados como posibles factores pron\u00f3sticos para prever la evoluci\u00f3n de la enfermedad. La actividad de la telomerasa (at), la longitud del tel\u00f3mero (lt) y la expresi\u00f3n del trf-1 (factor 1 de uni\u00f3n al tel\u00f3mero) han sido los factores escogidos para ser estudiados como factores pron\u00f3sticos por su implicaci\u00f3n en la regulaci\u00f3n y homeostasis de los tel\u00f3meros, los cuales tiene un papel importante en la estabilidad de l genoma, en la viabilidad celular y en el desarrollo carcinog\u00e9nico.  hip\u00f3tesis      estudiar dentro de nuestra serie de pacientes con c\u00e1ncer colorrectal (ccr) la actividad de la telomerasa, la longitud del telonero y la expresi\u00f3n del trf1, observar como se comportan dentro de la secuencia adenoma-carcinoma y determinar si pueden ser nuevos factores pron\u00f3sticos independientes para el tiempo libre de enfermedad y de supervivencia global.  pacientes y m\u00e9todos     la at fue determinada mediante la t\u00e9cnica f-trap en la mucosa tumoral, transicional, normal y en p\u00f3lipos colorrectales. La lt se analiz\u00f3 mediante southern blot en las mucosas tumoral y normal, en p\u00f3lipos y sangre de pacientes con ccr y en sangre y mucosa col\u00f3nica de pacientes sin ninguna afectaci\u00f3n colorrectal. La expresi\u00f3n del trf1 fue determinada por western blot en las mucosas tumoral y normal de pacientes con ccr. Se relacionaron la at, la lt y la expresi\u00f3n del trf1 entre s\u00ed y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Comportamiento y regulaci\u00f3n de los telometos en la carcinogenesis colorectal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Comportamiento y regulaci\u00f3n de los telometos en la carcinogenesis colorectal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Valls Bautista <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Lleida<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carme Pi\u00f1ol Felis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: josep Mar\u00eda Re\u00f1e espinet <\/li>\n<li>Manuel Armengol carrasco (vocal)<\/li>\n<li>josep antoni Bomb\u00ed latorre (vocal)<\/li>\n<li>xavier Dolcet roca (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Valls Bautista La neoplasia colorrectal ocupa el segundo lugar entre las m\u00e1s frecuentes y tambi\u00e9n es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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