{"id":58802,"date":"2007-01-06T00:00:00","date_gmt":"2007-01-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-tgf-b1-y-del-factor-de-transcripcion-snail-sobre-la-expresion-de-cox-2-en-celulas-mesangiales-humanas\/"},"modified":"2007-01-06T00:00:00","modified_gmt":"2007-01-06T00:00:00","slug":"efecto-de-tgf-b1-y-del-factor-de-transcripcion-snail-sobre-la-expresion-de-cox-2-en-celulas-mesangiales-humanas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/nefrologia\/efecto-de-tgf-b1-y-del-factor-de-transcripcion-snail-sobre-la-expresion-de-cox-2-en-celulas-mesangiales-humanas\/","title":{"rendered":"Efecto de tgf-b1 y del factor de transcripci\u00f3n snail sobre la expresi\u00f3n de cox-2 en c\u00e9lulas mesangiales humanas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Dorado Plaza <\/strong><\/h2>\n<p>Las patolog\u00edas renales tienen gran trascendencia en la sociedad debido a su elevada incidencia y al car\u00e1cter cr\u00f3nico de muchas de ellas, ocasionando un alto gasto sanitario y una alta incapacidad en los pacientes que las sufren. Muchas patolog\u00edas renales terminan ocasionando una insuficiencia renal cr\u00f3nica que necesita de di\u00e1lisis o transplante renal como tratamient\u00f3. Las c\u00e9lulas mesangiales est\u00e1n localizadas en los glom\u00e9rulos renales y tienen gran importancia ya que sintetizan diversos factores involucrados en dichas patolog\u00edas y responden a los mismos favoreciendo su progresi\u00f3n. El factor de crecimiento transformante beta (tgf-beta) est\u00e1 implicado en diversas patolog\u00edas relacionadas con una excesiva deposici\u00f3n de matriz extracelular, proceso que a nivel renal desencadena fibrosis e insuficiencia renal cr\u00f3nica. Otro factor importante en las patolog\u00edas renales es la ciclooxigenasa 2 (cox-2), enzima fundamental en la s\u00edntesis de prostaglandinas proinflamatorias en el presente trabajo hemos estudiado la expresi\u00f3n de cox-2 en respuesta a tgf-betal en c\u00e9lulas mesangiales humanas, ya que, hasta el momento, se desconoce si existe relaci\u00f3n entre ambas en este tipo celular. Adem\u00e1s, hemos estudiado las v\u00edas de se\u00f1alizaci\u00f3n implicadas en este proceso, ya que \u00e9stas son posibles dianas para el tratamiento farmacol\u00f3gico de las enfermedades renales. Por \u00faltimo, hemos estudiado la posible implicaci\u00f3n del factor de transcripci\u00f3n snail en la expresi\u00f3n de cox-2 inducida por tgf-betal en c\u00e9lulas mesangiales humanas. El factor de transcripci\u00f3n snail puede inducir transici\u00f3n epitelial-mesenquimal proceso fundamental en el desarrollo embrionario y en la progresi\u00f3n de tumores. Por tanto, en este trabajo hemos estudiado por primera vez la posible implicaci\u00f3n de snail en un proceso distinto a la transici\u00f3n epitelial-mesenquimal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de tgf-b1 y del factor de transcripci\u00f3n snail sobre la expresi\u00f3n de cox-2 en c\u00e9lulas mesangiales humanas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de tgf-b1 y del factor de transcripci\u00f3n snail sobre la expresi\u00f3n de cox-2 en c\u00e9lulas mesangiales humanas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Dorado Plaza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Miguel Lopez Novoa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Perez barriocanal <\/li>\n<li>M\u00aa piedad Ru\u00edz torres (vocal)<\/li>\n<li>azucena Esparis ogando (vocal)<\/li>\n<li>hector Peinado selgas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Dorado Plaza Las patolog\u00edas renales tienen gran trascendencia en la sociedad debido a su elevada incidencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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