{"id":58930,"date":"2007-11-06T00:00:00","date_gmt":"2007-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/apoptosis-neuronal-en-pacientes-con-dano-cerebral-traumatico-o-hemorragico-estudio-comparativo-in-vivo-in-vitro-y-post-mortem\/"},"modified":"2007-11-06T00:00:00","modified_gmt":"2007-11-06T00:00:00","slug":"apoptosis-neuronal-en-pacientes-con-dano-cerebral-traumatico-o-hemorragico-estudio-comparativo-in-vivo-in-vitro-y-post-mortem","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia\/apoptosis-neuronal-en-pacientes-con-dano-cerebral-traumatico-o-hemorragico-estudio-comparativo-in-vivo-in-vitro-y-post-mortem\/","title":{"rendered":"Apoptosis neuronal en pacientes con da\u00f1o cerebral traum\u00e1tico o hemorr\u00e1gico. estudio comparativo in vivo, in vitro y post-mortem"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  \u00e1ngeles Ballesteros Sanz <\/strong><\/h2>\n<p>La apoptosis neuronal desempe\u00f1a un importante papel en la etiopatogenia de gran cantidad de procesos neurodegenerativos y de lesiones neurol\u00f3gicas agudas, entre las cuales se encuentran el da\u00f1o cerebral traum\u00e1tico o hemorr\u00e1gico. el da\u00f1o cerebral agudo representa un problema sanitario grave dada su elevada preValencia y alta morbi-mortalidad, por lo que es un \u00e1rea de intensa investigaci\u00f3n. El suero regional cerebral de los pacientes con traumatismo craneo-encef\u00e1lico o hemorragia intracraneal espont\u00e1nea grave, presenta alg\u00fan factor soluble capaz de inducir apoptosis in vitro en c\u00e9lulas neuronales. La tasa de apoptosis precoz in vitro, as\u00ed como los par\u00e1metros de gravedad al ingreso en la unidad de cuidados intensivos, se relacionan con la mortalidad a los seis meses. La tasa de apoptosis precoz in vitro fue el \u00fanico factor independiente de mortalidad a los seis meses. Este modelo in vitro  junto con los par\u00e1metros cl\u00ednicos y radiol\u00f3gicos pueden mejorar el valor de los modelos pron\u00f3sticos que eval\u00faan el da\u00f1o cerebral. La neuronas con morfolog\u00eda de apoptosis fueron detectadas en las muestras cerebrales. la expresi\u00f3n de prote\u00ednas antiapopt\u00f3ticas (bcl 2 y bcl-xl) es mayor en la zona periconstusional de las muestras cerebrales de pacientes con buena recuperaci\u00f3n despu\u00e9s de la agresi\u00f3n cerebral, que la detectada en la misma zona, pero de muestras procedentes de pacientes fallecidos por un traumatismo craneo-encef\u00e1lico. Se confirma la presencia de apoptosis neuronal como forma prominente de muerte celular en la zona perilesional de contusiones cerebrales humanas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Apoptosis neuronal en pacientes con da\u00f1o cerebral traum\u00e1tico o hemorr\u00e1gico. estudio comparativo in vivo, in vitro y post-mortem<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Apoptosis neuronal en pacientes con da\u00f1o cerebral traum\u00e1tico o hemorr\u00e1gico. estudio comparativo in vivo, in vitro y post-mortem <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  \u00e1ngeles Ballesteros Sanz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Vazquez Barquero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco j. (secretario) Sigols ladron de guevara <\/li>\n<li>Jes\u00fas Garibi ondabarrena (vocal)<\/li>\n<li>Jes\u00fas Merino perez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda \u00e1ngeles Ballesteros Sanz La apoptosis neuronal desempe\u00f1a un importante papel en la etiopatogenia de gran cantidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[10518,155,141,1737,156],"tags":[130226,130227,130228,10670,130225],"class_list":["post-58930","post","type-post","status-publish","format-standard","hentry","category-cantabria","category-ciencias-clinicas","category-cirugia","category-inmunologia","category-patologia","tag-alfonso-vazquez-barquero","tag-francisco-j-secretario-sigols-ladron-de-guevara","tag-jesus-garibi-ondabarrena","tag-jesus-merino-perez","tag-maria-angeles-ballesteros-sanz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=58930"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/58930\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=58930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=58930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=58930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}