{"id":59026,"date":"2018-03-09T22:46:53","date_gmt":"2018-03-09T22:46:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-vitamina-b12-en-la-sa%c2%adntesis-de-carotenos-regulada-por-la-luz-en-myxococcus-xanthus\/"},"modified":"2018-03-09T22:46:53","modified_gmt":"2018-03-09T22:46:53","slug":"papel-de-la-vitamina-b12-en-la-sa%c2%adntesis-de-carotenos-regulada-por-la-luz-en-myxococcus-xanthus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ingenieria-genetica\/papel-de-la-vitamina-b12-en-la-sa%c2%adntesis-de-carotenos-regulada-por-la-luz-en-myxococcus-xanthus\/","title":{"rendered":"Papel de la vitamina b12 en la s\u00edntesis de carotenos regulada por la luz en myxococcus xanthus"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  P\u00e9rez Mar\u00edn Mari Cruz <\/strong><\/h2>\n<p>La bacteria myxococcus xanthus responde a la luz azul con la s\u00edntesis de carotenos, mol\u00e9culas fotoprotectoras que evitan el da\u00f1o celular. La mayor\u00eda delos genes carotenog\u00e9nicos se encuentran agrupados en un oper\u00f3n de expresi\u00f3n fotoinducible denominado carb. Estudios previos indicaban que la expresi\u00f3n de carb estaba regulada por las prote\u00ednas cara y cars. Cara bloquea en la oscuridad la actividad del promotor de carb (pb), y ejerce su acci\u00f3n represora uni\u00e9ndose de forma espec\u00edfica a la regi\u00f3n promotora\/operadora de dicho oper\u00f3n . cars, por el contrario, act\u00faa como un antirrepresor y ejerce su acci\u00f3n activadora interaccionando f\u00edsicamente con cara e inhibiendo as\u00ed la uni\u00f3n de esta \u00faltima al dna. La prote\u00edna cara presenta una organizaci\u00f3n novedosa de dominios. El extremo amino, caranter, es un domino de uni\u00f3n a dna similar al de los factores transcripcionales de la familia merr. El extremo carboxilo, caracter, media la oligomerizaci\u00f3n de cara e incluye en su secuencia un motivo consenso de uni\u00f3n a cobalaminas, como la vitamina b12, presente en arias enzimas que utilizan dicho compuesto como cofactor. En m.Xanthus, se hab\u00eda descrito la existencia de una prote\u00edna, ahora llamada carh, de funci\u00f3n desconocida y cuya secuencia predec\u00eda la asociaci\u00f3n de dominios descrita para cara. Dado que la acci\u00f3n reguladora de las prote\u00ednas merr es modulada pro la uni\u00f3n de un ligando a su extremo carboxilo, en este trabajo se analiz\u00f3 el posible papel de la vitamina b12 en la regulaci\u00f3n de pb mediada por cara o carh. A pesar de que caracter se une a la vitamina b12 in vitro y que dicha uni\u00f3n favorece la oligomerizaci\u00f3n de cara, dicho compuesto no parece jugar un papel importante en la represi\u00f3n de pb mediada por cara. Sin embargo, el an\u00e1lisis en profundidad de carh revel\u00f3 que esta prote\u00edna act\u00faa tambi\u00e9n como represero del promotor pb y que a diferencia de cara, s\u00ed requiere de la presencia de vitamina b12 para ejercer su acci\u00f3n represora. La acc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la vitamina b12 en la s\u00edntesis de carotenos regulada por la luz en myxococcus xanthus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la vitamina b12 en la s\u00edntesis de carotenos regulada por la luz en myxococcus xanthus <\/li>\n<li><strong>Autor:<\/strong>\u00a0  P\u00e9rez Mar\u00edn Mari Cruz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Monserrat Elias Arnanz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ram\u00f3n D\u00edaz orejas <\/li>\n<li>Luis Ramos Juan (vocal)<\/li>\n<li>josep Casades\u00fas (vocal)<\/li>\n<li>rosa Mar\u00eda Ruiz vazquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de P\u00e9rez Mar\u00edn Mari Cruz La bacteria myxococcus xanthus responde a la luz azul con la s\u00edntesis de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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