{"id":59147,"date":"2018-03-09T22:46:59","date_gmt":"2018-03-09T22:46:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-sa%c2%adntesis-y-evaluacion-de-inhibidores-de-dimerizacion-de-la-proteasas-del-vih-1\/"},"modified":"2018-03-09T22:46:59","modified_gmt":"2018-03-09T22:46:59","slug":"diseno-sa%c2%adntesis-y-evaluacion-de-inhibidores-de-dimerizacion-de-la-proteasas-del-vih-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/barcelona\/diseno-sa%c2%adntesis-y-evaluacion-de-inhibidores-de-dimerizacion-de-la-proteasas-del-vih-1\/","title":{"rendered":"Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n de inhibidores de dimerizaci\u00f3n de la proteasas del vih-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eul\u00c1\u00a0lia Pinyol Oll\u00e9 <\/strong><\/h2>\n<p>Una de las estrategias que se viene estudiando desde 1997 para el desarrollo de f\u00e1rmacos activos contra el virus hiv-1 consiste en preparar compuestos que inhiban la dimerizaci\u00f3n dela proteasas del virus, puesto que esta dimerizaci\u00f3n es imprescindible para el ciclo de vida del virus. La proteasa de hiv-1 es una prote\u00edna de 99 amino\u00e1cidos, cuya interfase de dimerizaci\u00f3n est\u00e1 formada por la interdigitaci\u00f3n de los extremos terminales en una estructura de l\u00e1mina beta antiparalela.     as\u00ed, el grupo de chmielewski ha desarrollado una serie de compuestos que consisten en las zonas pept\u00eddicas de interacci\u00f3n unidas entre s\u00ed por una cadena carbonada.     en la presente tesis doctoral se ha desarrollado una colecci\u00f3n de inhibidores de la dimerizaci\u00f3n de la proteasas del hiv del mismo estilo, en que introducimos nuestras 3-amino-2-piperidonas, que mimetizan giros, en las zonas que unen las cadenas pept\u00eddicas con el \u00ablinker\u00bb carbonado. Con esto se rigidifica la mol\u00e9cula de forma que encaje mejor con la proteasas monom\u00e9rica, con la finalidad de aumentar as\u00ed su capacidad de inhibici\u00f3n.     se han sintetizado 3 colecciones de inhibidores:     * los inhibidores patr\u00f3n, formado en su totalidad por amino\u00e1cidos naturales.     * los inhibidores de tipo , formados por una \u00fanica cadena pept\u00eddica que incorpora una de las lactamas desarrolladas en nuestro grupo.     * los inhibidores de tipo ii, formados pro dos cadenas pept\u00eddicas unidas mediante un linker alif\u00e1tico.     una vez obtenidos los compuestos se han evaluado \u00abin vitro\u00bb mediante un ensayo de fluorescencia y \u00abin vivo\u00bb, gracias a la colaboraci\u00f3n con el grupo de investigaci\u00f3n del dr. Jos\u00e9 est\u00e9 del hospital germans trias i pujol.      algunos compuestos han mostrado actividad \u00abin vitro\u00bb e \u00abin vivo\u00bb, destacando el compuesto 176 por su actividad sobre virus mutantes.     finalmente, tambi\u00e9n se ha estudiado la interacci\u00f3n de este inhibidor con la hiv-1 pr mediante microcalor\u00edmetria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n de inhibidores de dimerizaci\u00f3n de la proteasas del vih-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, s\u00edntesis y evaluaci\u00f3n de inhibidores de dimerizaci\u00f3n de la proteasas del vih-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eul\u00c1\u00a0lia Pinyol Oll\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Anna Ma. Diez Pascual<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ernest Giralt lledo <\/li>\n<li>angel Messeguer peypoch (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Camarasa rius (vocal)<\/li>\n<li>ernesto Nicolas galindo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eul\u00c1\u00a0lia Pinyol Oll\u00e9 Una de las estrategias que se viene estudiando desde 1997 para el desarrollo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1104,951,1412],"tags":[18986,49962,1100,60919,130685,43780],"class_list":["post-59147","post","type-post","status-publish","format-standard","hentry","category-aminoacidos","category-barcelona","category-compuestos-heterociclicos","tag-angel-messeguer-peypoch","tag-anna-ma-diez-pascual","tag-ernest-giralt-lledo","tag-ernesto-nicolas-galindo","tag-eula-lia-pinyol-olle","tag-maria-jose-camarasa-rius"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59147"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59147\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}