{"id":59166,"date":"2018-03-09T22:46:59","date_gmt":"2018-03-09T22:46:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sistema-cannabinoide-y-neuroinflamacion-implicaciones-terapeuticas-en-un-modelo-viral-de-esclerosis-multiple\/"},"modified":"2018-03-09T22:46:59","modified_gmt":"2018-03-09T22:46:59","slug":"sistema-cannabinoide-y-neuroinflamacion-implicaciones-terapeuticas-en-un-modelo-viral-de-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sistema-cannabinoide-y-neuroinflamacion-implicaciones-terapeuticas-en-un-modelo-viral-de-esclerosis-multiple\/","title":{"rendered":"Sistema cannabinoide y neuroinflamaci\u00f3n: implicaciones terap\u00e9uticas en un modelo viral de esclerosis m\u00faltiple"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Leyre Mestre Nieto <\/strong><\/h2>\n<p>La regulaci\u00f3n del sistema cannabinoide end\u00f3geno mediante la administraci\u00f3n de inhibidores de la recaptaci\u00f3n de anandamida supone una mejora en la sintomatolog\u00eda motora de ratones que presentan un modelo experimental de esclerosis m\u00faltiple primaria progresiva (enfermedad desmielinizante incluida por la infecci\u00f3n con el virus de theiler (tmev-idd)). Asimismo, la presencia de infiltrados celulares tanto en cerebro como en m\u00e9dula espinal se vi\u00f3 limitada por la acci\u00f3n de estos compuestos. El estudio tanto in vivo como in vitro de la regulaci\u00f3n de las mol\u00e9culas de adhesi\u00f3n implicadas en el proceso de transmigraci\u00f3n celular revela que los cannabinoides son capaces de modificar la expresi\u00f3n tanto de vcam-1 como de icam-1 mediante la activaci\u00f3n de rutas que implican a pi3k, p38 y p42\/44 mapk. Adem\u00e1s, el estudio in vitro de la regulaci\u00f3n de la enzima cox-2 (implicada en la permeabilidad de la microvasculatura cerebral) en c\u00e9lulas endoteliales cerebrales infectadas por el virus de theiler indica que los cannabinoides son potenciales reguladores de la expresi\u00f3n de esta enzima.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sistema cannabinoide y neuroinflamaci\u00f3n: implicaciones terap\u00e9uticas en un modelo viral de esclerosis m\u00faltiple<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sistema cannabinoide y neuroinflamaci\u00f3n: implicaciones terap\u00e9uticas en un modelo viral de esclerosis m\u00faltiple <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Leyre Mestre Nieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Guaza Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li>Bernardo Castellano L\u00f3pez (vocal)<\/li>\n<li>Antonio Garc\u00eda Merino (vocal)<\/li>\n<li>Juli\u00e1n Romero Paredes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Leyre Mestre Nieto La regulaci\u00f3n del sistema cannabinoide end\u00f3geno mediante la administraci\u00f3n de inhibidores de la recaptaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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