{"id":59192,"date":"2018-03-09T22:47:03","date_gmt":"2018-03-09T22:47:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracteritzacio-del-mecanisme-de-transfera%c2%a8ncia-del-vih-1-entre-ca%c2%a8l-lules\/"},"modified":"2018-03-09T22:47:03","modified_gmt":"2018-03-09T22:47:03","slug":"caracteritzacio-del-mecanisme-de-transfera%c2%a8ncia-del-vih-1-entre-ca%c2%a8l-lules","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracteritzacio-del-mecanisme-de-transfera%c2%a8ncia-del-vih-1-entre-ca%c2%a8l-lules\/","title":{"rendered":"Caracteritzaci\u00f3 del mecanisme de transfer\u00e9ncia del vih-1 entre c\u00e9l.lules"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Berta Bosch Pag\u00e9s <\/strong><\/h2>\n<p>La transmisi\u00f3n del vih-1 entre c\u00e9lulas es uno de los mecanismos m\u00e1s eficientes de diseminaci\u00f3n del virus. Los contactos celulares entre c\u00e9lulas infectadas por el vih-1 y linfocitos t cd4+ no infectados pueden desencadenar la formaci\u00f3n de sincitios, la muerte de la c\u00e9lula diana por apoptosis o la transferencia de ant\u00edgenos virales a trav\u00e9s de la sinapsis virol\u00f3gica. En este trabajo, hemos caracterizado la din\u00e1mica del proceso de transferencia de ant\u00edgenos del vih-1 entre c\u00e9lulas t y hemos identificado mecanismos celulares involucrados en este proceso y el destino de los ant\u00edgenos v\u00edricos transferidos. El mecanismo de transferencia del vih-1 era completamente dependiente de la interacci\u00f3n de la gp120 con el receptor cd4, expresados en la superficie de las c\u00e9lulas t efectoras infectadas con el vih-1 y de los linfocitos t cd4+ diana, respectivamente. La ausencia del correceptor adecuado o el bloqueo de los procesos de fusi\u00f3n o de transcripci\u00f3n inversa no evitaron la transferencia de ant\u00edgenos v\u00edricos, sugiriendo que la uni\u00f3n de la gp120 con cd4 era la \u00fanica etapa del ciclo de replicaci\u00f3n del vih-1 estrictamente necesaria para la transferencia de ant\u00edgenos del vih-1 entre c\u00e9lulas t. En las c\u00e9lulas diana se observ\u00f3 la polarizaci\u00f3n del receptor cd4 a la regi\u00f3n subcelular donde los ant\u00edgenos del vih-1 eran transferidos. Adem\u00e1s, un citoesqueleto de actina funcional era necesario para la transferencia de estos ant\u00edgenos. El an\u00e1lisis con microscopia electr\u00f3nica de los linfocitos diana mostr\u00f3 la presencia de part\u00edculas completas del vih-1 en ves\u00edculas intracelulares, revelando que un proceso endoc\u00edtico pod\u00eda participar en la transferencia del vih-1 entre c\u00e9lulas t. En este aspecto, se identific\u00f3 la endocitosis dependiente de clatrina como la ruta endoc\u00edtica involucrada en este proceso. La mayor\u00eda de los ant\u00edgenos del vih-1 internalizados en las c\u00e9lulas diana no colocalizaban con lamp1, marcador de la ruta lisosomal de degradaci\u00f3n,<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracteritzaci\u00f3 del mecanisme de transfer\u00e9ncia del vih-1 entre c\u00e9l.lules<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracteritzaci\u00f3 del mecanisme de transfer\u00e9ncia del vih-1 entre c\u00e9l.lules <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Berta Bosch Pag\u00e9s <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Andr\u00e9s Est\u00e9 Araque<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pere joan Cardona iglesias <\/li>\n<li>jaume Farr\u00e9s vic\u00e9n (vocal)<\/li>\n<li>mireia Gim\u00e9nez barcons (vocal)<\/li>\n<li>francesc Borr\u00ed\u00a0s serres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Berta Bosch Pag\u00e9s La transmisi\u00f3n del vih-1 entre c\u00e9lulas es uno de los mecanismos m\u00e1s eficientes de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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