{"id":59221,"date":"2018-03-09T22:47:03","date_gmt":"2018-03-09T22:47:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/neurorreparacion-mediada-por-celulas-progenitoras-endoteliales-en-el-ictus-isquemico-influencia-de-factores-de-proliferacion-y-migracion-celular-endogenos\/"},"modified":"2018-03-09T22:47:03","modified_gmt":"2018-03-09T22:47:03","slug":"neurorreparacion-mediada-por-celulas-progenitoras-endoteliales-en-el-ictus-isquemico-influencia-de-factores-de-proliferacion-y-migracion-celular-endogenos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/neurorreparacion-mediada-por-celulas-progenitoras-endoteliales-en-el-ictus-isquemico-influencia-de-factores-de-proliferacion-y-migracion-celular-endogenos\/","title":{"rendered":"Neurorreparaci\u00f3n mediada por c\u00e9lulas progenitoras endoteliales en el ictus isqu\u00e9mico: influencia de factores de proliferaci\u00f3n y migraci\u00f3n celular end\u00f3genos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Tomas Sobrino Moreiras <\/strong><\/h2>\n<p>El ictus es el desarrollo cl\u00ednico r\u00e1pido de signos focales de alteraci\u00f3n de la funci\u00f3n cerebral sin otra causa aparente que no sea el origen vascular. constituye la segunda causa de muerte y la primera de morbilidad en espa\u00f1a. La neuroprotecci\u00f3n farmacol\u00f3gica, ampliamente eficaz en modelos experimentales de isquemia cerebral, no se ha mostrado beneficiosa en la pr\u00e1ctica cl\u00ednica a pesar del amplio n\u00famero de agentes estudiados en ensayos cl\u00ednicos, debi\u00e9ndose abrir nuevos desarrollos terap\u00e9uticos. En este sentido, las c\u00e9lulas progenitoras endoteliales (epcs) son una estirpe de c\u00e9lulas madre adultas, derivadas de la m\u00e9dula \u00f3sea, que median procesos de neovascularizaci\u00f3n, reendotelizaci\u00f3n y reparaci\u00f3n del endotelio vascular, en respuesta a una isquemia tisular o a un trauma vascular, promovidas por factores moleculares que activan su proliferaci\u00f3n tales como el vegf, la sdf-1 alfa y la mmp-9 activa. Este trabajo de investigaci\u00f3n ha estudiado la influencia de las concentraciones de epcs en sangre perif\u00e9rica sobre el pron\u00f3stico funcional de pacientes que sufrieron un ictus isqu\u00e9mico agudo. De igual modo, se plante\u00f3 confirmar que los niveles s\u00e9ricos de vegf, sdf-1 alfa y mmp-9 activa se asocian con el incremento de las concentraciones de epcs y con el pron\u00f3stico funcional, as\u00ed como estudiar la influencia de los f\u00e1rmacos administrados en fase aguda (estatinas, citocolina y tpa) sobre la concentraci\u00f3n de epcs cirulantes en sangre perif\u00e9rica. en el estudio se incluyeron 48 pacientes (24 hombres, edad media, 70.9 (10.1) a\u00f1os) y con primer episodio de ictus isqu\u00e9mico no lacunar, de mayor 12 horas de evoluci\u00f3n. La evoluci\u00f3n cl\u00ednica neurol\u00f3gica se valor\u00f3  mediante la nihss a igual escala temporal (al ingreso, 24 y 72 hora, d\u00eda 7 y a los 3 meses) que las determinaciones bioqu\u00edmicas (niveles s\u00e9ricos de vegf, sdf-1 alfa y mmo-9 activa determinados por t\u00e9cnicas elisa). La evoluci\u00f3n funcional de los pacientes se valor\u00f3 por la escala rankin<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Neurorreparaci\u00f3n mediada por c\u00e9lulas progenitoras endoteliales en el ictus isqu\u00e9mico: influencia de factores de proliferaci\u00f3n y migraci\u00f3n celular end\u00f3genos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Neurorreparaci\u00f3n mediada por c\u00e9lulas progenitoras endoteliales en el ictus isqu\u00e9mico: influencia de factores de proliferaci\u00f3n y migraci\u00f3n celular end\u00f3genos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Tomas Sobrino Moreiras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Castillo S\u00e1nchez Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Casanuevas freijo <\/li>\n<li>julio Pascual g\u00f3mez (vocal)<\/li>\n<li> Moro s\u00e1nchez Mar\u00eda \u00e1ngeles (vocal)<\/li>\n<li> Castellanos rodrigo Mar\u00eda del mar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tomas Sobrino Moreiras El ictus es el desarrollo cl\u00ednico r\u00e1pido de signos focales de alteraci\u00f3n de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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