{"id":5924,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/factores-que-influyen-en-el-aislamiento-y-la-eficacia-del-alotrasplante-de-islotes-pancreaticos-en-la-rata-wistar\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"factores-que-influyen-en-el-aislamiento-y-la-eficacia-del-alotrasplante-de-islotes-pancreaticos-en-la-rata-wistar","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-que-influyen-en-el-aislamiento-y-la-eficacia-del-alotrasplante-de-islotes-pancreaticos-en-la-rata-wistar\/","title":{"rendered":"Factores que influyen en el aislamiento y la eficacia del alotrasplante de islotes pancreaticos en la rata wistar."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Arranz Martin Jos\u00e9 Alfonso <\/strong><\/h2>\n<p>Se recogen una serie de experiencias sobre el aislamiento de islotes pancreaticos de rata obtenidos mediante la digestion con colagenasa y purificacion de gradientes de bsa, asi como la eficacia del alotrasplante en fresco via intraportal a ratas con diabetes inducida experimentalmente, introduciendo como unico factor de manipulacion inmunologica la administracion perioperatoria de ciclosporina (csa). Se han realizado un total de 103 trasplantes distribuidos en funcion de la pauta de csa empleada. Mientras que los trasplantes realizados sin inmunosupresion o con pauta de csa oral no muestran en ningun caso una remision mantenida de la diabetes, la administracion subcutanea (sc) de csa perioperatoria posibilita una remision prolongada.  superando unos determinados valores de masa y pureza insular (900 islotes y 40% respectivamente), no se observa una relacion significativa entre la respuesta obtenida tras el trasplante y los mencionados parametros.  la pauta de administracion los dias 0, 1 y 2 postrasplante no ha sido superada por otras pautas que anticipan o prolongan la inmunosupresion. La biodisponibilidad de la csa administrada por via sc resulta claramente superior a la enteral, aun con una importante variabilidad, lo que podria explicar las diferencias obtenidas con las distintas pautas y la heterogeneidad del resultado en los trasplantes que comparten la misma pauta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores que influyen en el aislamiento y la eficacia del alotrasplante de islotes pancreaticos en la rata wistar.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores que influyen en el aislamiento y la eficacia del alotrasplante de islotes pancreaticos en la rata wistar. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Arranz Martin Jos\u00e9 Alfonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonino Jara Albarran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Tamarit Rodriguez <\/li>\n<li>Santiago Dur\u00e1n Garc\u00eda (vocal)<\/li>\n<li>Juan  Pedro Mara\u00f1es  Pallardo (vocal)<\/li>\n<li>Luis Felipe Pallardo Sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arranz Martin Jos\u00e9 Alfonso Se recogen una serie de experiencias sobre el aislamiento de islotes pancreaticos de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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