{"id":59268,"date":"2018-03-09T22:47:06","date_gmt":"2018-03-09T22:47:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/establecimiento-de-un-modelo-experimental-para-el-estudio-de-la-leishmaniosis-estrategias-de-inmunizacion-con-las-histonas-de-leishmania-frente-a-leishmaniosis-cutanea-y-visceral\/"},"modified":"2018-03-09T22:47:06","modified_gmt":"2018-03-09T22:47:06","slug":"establecimiento-de-un-modelo-experimental-para-el-estudio-de-la-leishmaniosis-estrategias-de-inmunizacion-con-las-histonas-de-leishmania-frente-a-leishmaniosis-cutanea-y-visceral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/establecimiento-de-un-modelo-experimental-para-el-estudio-de-la-leishmaniosis-estrategias-de-inmunizacion-con-las-histonas-de-leishmania-frente-a-leishmaniosis-cutanea-y-visceral\/","title":{"rendered":"Establecimiento de un modelo experimental para el estudio de la leishmaniosis. estrategias de inmunizacion con las histonas de leishmania frente a leishmaniosis cutanea y visceral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Carri\u00f3n Herrero <\/strong><\/h2>\n<p>Las leishmaniosis constituyen un amplio rango de enfermedades transmitidas por vector y causadas por par\u00e1sitos protozoos del g\u00e9nero leishmania. Se han desarrollado varios modelos animales experimentales a lo largo de los a\u00f1os. Sin embargo, el nivel de protecci\u00f3n que confieren las vacunas contra leishmaniosis visceral es bajo, posiblemente debido a la falta de modelos apropiados para el estudio de la resistencia inmunitaria. Hemos analizado las caracter\u00edsticas inmunohistol\u00f3gicas inducidas en ratones balb\/c por la infecci\u00f3n intravenosa de 103, 105 y 106 par\u00e1sitos de leishmania infantum. Hemos encontrado que el desarrollo de algunos par\u00e1metros inmunohistol\u00f3gicos cuantificables era dependiente del tama\u00f1o de in\u00f3culo infectivo en los ratones. En este trabajo, hemos analizado el potencial de las c\u00e9lulas dendr\u00edticas cargadas con una mezcla de histonas de l. Infantum y la inmunizaci\u00f3n gen\u00e9tica con histonas dobles contra la leishmaniosis cut\u00e1nea y visceral en rat\u00f3n. Los mecanismos inmunitarios antileishmaniales de protecci\u00f3n resultaron ser dependientes de la capacidad de inducir una respuesta th1, una limitaci\u00f3n de la respuesta th2 y una baja frecuencia de c\u00e9lulas t reguladoras en el sitio de infecci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Establecimiento de un modelo experimental para el estudio de la leishmaniosis. estrategias de inmunizacion con las histonas de leishmania frente a leishmaniosis cutanea y visceral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Establecimiento de un modelo experimental para el estudio de la leishmaniosis. estrategias de inmunizacion con las histonas de leishmania frente a leishmaniosis cutanea y visceral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Carri\u00f3n Herrero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carlos Alonso Bedate<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda (secretario) Requena rolan\u00eda <\/li>\n<li>Carlos Gomez nieto (vocal)<\/li>\n<li>Mar\u00eda no Esteban rodriguez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Carri\u00f3n Herrero Las leishmaniosis constituyen un amplio rango de enfermedades transmitidas por vector y causadas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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