{"id":59299,"date":"2018-03-09T22:47:06","date_gmt":"2018-03-09T22:47:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/enfermedad-de-aujeszky-relacion-de-la-respuesta-inmunitaria-y-el-control-del-programa-apoptotico-en-la-patologa%c2%ada-y-patogenia-de-la-infeccion\/"},"modified":"2018-03-09T22:47:06","modified_gmt":"2018-03-09T22:47:06","slug":"enfermedad-de-aujeszky-relacion-de-la-respuesta-inmunitaria-y-el-control-del-programa-apoptotico-en-la-patologa%c2%ada-y-patogenia-de-la-infeccion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/enfermedad-de-aujeszky-relacion-de-la-respuesta-inmunitaria-y-el-control-del-programa-apoptotico-en-la-patologa%c2%ada-y-patogenia-de-la-infeccion\/","title":{"rendered":"Enfermedad de aujeszky: relaci\u00f3n de la respuesta inmunitaria y el control del programa apopt\u00f3tico en la patolog\u00eda y patogenia de la infecci\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andr\u00e9s Marcaccini Carpio <\/strong><\/h2>\n<p>En esta tesis doctoral se han estudiado diversos aspectos de la infecci\u00f3n por el virus de la enfermedad de aujeszky (vea) en cerdos y visones. Su desarrollo se dividi\u00f3 en dos experimentos independientes: en el primero se investig\u00f3 el desarrollo de la respuesta inmunitaria y el control del programa apopt\u00f3tico en el sistema nervioso (sn) de cerdos inoculados experimentalmente por el vea. Los resultados obtenidos demuestran que la invasi\u00f3n del sn por el vea provoca una r\u00e1pida respuesta inmunitaria innata constituida principalmente por macr\u00f3fagos y linfocitos t, con una importante participaci\u00f3n de c\u00e9lulas citot\u00f3xicas. La infecci\u00f3n adem\u00e1s indujo un notable incremento en la expresi\u00f3n de las principales isoformas de sintasas de \u00f3xido n\u00edtrico que coincidi\u00f3 en tiempo, localizaci\u00f3n y magnitud con la replicaci\u00f3n y diseminaci\u00f3n del virus. Respecto al control del programa apopt\u00f3tico, durante la infecci\u00f3n aguda el vea es capaz de inhibir la muerte neuronal de forma temporal, ya que las neuronas infectadas mueren finalmente por apoptosis. en el segundo experimento se investig\u00f3 el fundamento de la diferente patolog\u00eda y patogenia que exhibe la infecci\u00f3n por el vea en el vis\u00f3n. En el sn se detect\u00f3 un gran n\u00famero de c\u00e9lulas infectadas y una escasa reacci\u00f3n inflamatoria, observ\u00e1ndose adem\u00e1s la presencia de hemorragias y microhemorragias distribuidas en diferentes regiones del tejido nervioso. La utilizaci\u00f3n de la t\u00e9cnica de microdisecci\u00f3n l\u00e1ser  en combinaci\u00f3n con la reacci\u00f3n en cadena de la polimerasa permiti\u00f3 detectar el virus en los vasos sangu\u00edneos del tronco del enc\u00e9falo y de la corteza cerebral de los visones, confirmando el endoteliotropismo del vea en esta especie.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Enfermedad de aujeszky: relaci\u00f3n de la respuesta inmunitaria y el control del programa apopt\u00f3tico en la patolog\u00eda y patogenia de la infecci\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Enfermedad de aujeszky: relaci\u00f3n de la respuesta inmunitaria y el control del programa apopt\u00f3tico en la patolog\u00eda y patogenia de la infecci\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andr\u00e9s Marcaccini Carpio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Mar\u00eda Nieto Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda Casta\u00f1o rosado <\/li>\n<li>marti Pumarola batlle (vocal)<\/li>\n<li>Antonio Bernabe salazar (vocal)<\/li>\n<li>marisa Andrada borzollino (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Marcaccini Carpio En esta tesis doctoral se han estudiado diversos aspectos de la infecci\u00f3n por el 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