{"id":59340,"date":"2018-03-09T22:47:10","date_gmt":"2018-03-09T22:47:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-administracion-pulmonar-de-farmacos-mediante-un-modelo-de-pulmon-aislado-de-rata\/"},"modified":"2018-03-09T22:47:10","modified_gmt":"2018-03-09T22:47:10","slug":"estudio-de-la-administracion-pulmonar-de-farmacos-mediante-un-modelo-de-pulmon-aislado-de-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacodinamia\/estudio-de-la-administracion-pulmonar-de-farmacos-mediante-un-modelo-de-pulmon-aislado-de-rata\/","title":{"rendered":"Estudio de la administraci\u00f3n pulmonar de f\u00e1rmacos mediante un modelo de pulm\u00f3n aislado de rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Jos\u00e9 De Jesus Valle <\/strong><\/h2>\n<p>La administraci\u00f3n pulmonar constituye una ruta alternativa excelente para las generaciones de nuevos medicamentos obtenidos por procedimientos biotecnol\u00f3gicos con baja biodisponibilidad oral, as\u00ed como un m\u00e9todo de orientaci\u00f3n pasiva de las drogas que act\u00faan a nivel pulmonar como los antibi\u00f3ticos.  los objetivos de este estudio han sido el de caracterizar el comportamiento cin\u00e9tico de una serie de antibi\u00f3ticos que se administran por v\u00eda sist\u00e9mica y respiratoria y evaluar la influencia del \u00abpatr\u00f3n respiratorio\u00bb en la disposici\u00f3n pulmonar por las distintas v\u00edas.  el estudio se realiz\u00f3 con 96 ratas wistar, distribuidas en 16 grupos tratados con ciprofloxacino, levofloxacino y linezolid vancomicina en diferentes condiciones experimentales (60 y 30 respiraciones por minuto, 2 y 4 ml de volumen de marea). Las muestras de l\u00edquido eferentes se recopilaron mediante un colector de fracciones previamente programadas. Las muestras del l\u00edquido del lavado broncoalveolar y tejido pulmonar se realizaron al final de cada experiencia. Concentraciones de antibi\u00f3ticos en todas las muestras se midieron utilizando t\u00e9cnicas de hplc con detecci\u00f3n ultravioleta y fluorescencia.  la comparaci\u00f3n de ambas v\u00edas de administraci\u00f3n y an\u00e1lisis de los datos revelan que la administraci\u00f3n pulmonar produce concentraciones en el l\u00edquido broncoalveolar y tejido pulmonar son mucho m\u00e1s altos que los obtenidos tras la administraci\u00f3n sist\u00e9mica de cuatro antibi\u00f3ticos estudiados. El patr\u00f3n respiratorio correspondientes a 30 respiraciones por minuto y 4 ml de volumen corriente parece mejorar el proceso de transferencia a trav\u00e9s de \u00abalv\u00e9olo-epitelial\u00bb barrera de los cuatro antibi\u00f3ticos, ya que conduce a niveles m\u00e1s altos en el fluido l\u00edquido broncoalveolar eferentes y, como resultado de una aumento de la superficie de absorci\u00f3n junto con el aumento del tiempo de residencia de la droga en ese espacio<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la administraci\u00f3n pulmonar de f\u00e1rmacos mediante un modelo de pulm\u00f3n aislado de rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la administraci\u00f3n pulmonar de f\u00e1rmacos mediante un modelo de pulm\u00f3n aislado de rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Jos\u00e9 De Jesus Valle <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Amparo Sanchez Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Jes\u00fas Dominguez gil hurle <\/li>\n<li>felix Dias carvalho (vocal)<\/li>\n<li>Mar\u00eda  dolores Lude\u00f1a de la cruz (vocal)<\/li>\n<li>angel Concheiro nine (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Jos\u00e9 De Jesus Valle La administraci\u00f3n pulmonar constituye una ruta alternativa excelente para las generaciones de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[189,9386],"tags":[3222,9483,3014,131105,25669,131104],"class_list":["post-59340","post","type-post","status-publish","format-standard","hentry","category-farmacodinamia","category-salamanca","tag-alfonso-jesus-dominguez-gil-hurle","tag-amparo-sanchez-navarro","tag-angel-concheiro-nine","tag-felix-dias-carvalho","tag-maria-dolores-ludena-de-la-cruz","tag-maria-jose-de-jesus-valle"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59340"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59340\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}