{"id":59349,"date":"2018-03-09T22:47:10","date_gmt":"2018-03-09T22:47:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sarcoma-de-ewing-nuevas-aproximaciones-terapeuticas-y-busqueda-de-dianas-biologicas-del-oncogen-ews-fli-1\/"},"modified":"2018-03-09T22:47:10","modified_gmt":"2018-03-09T22:47:10","slug":"sarcoma-de-ewing-nuevas-aproximaciones-terapeuticas-y-busqueda-de-dianas-biologicas-del-oncogen-ews-fli-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sarcoma-de-ewing-nuevas-aproximaciones-terapeuticas-y-busqueda-de-dianas-biologicas-del-oncogen-ews-fli-1\/","title":{"rendered":"Sarcoma de ewing: nuevas aproximaciones terapeuticas y busqueda de dianas biologicas del oncogen ews\/fli-1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Mateo Lozano <\/strong><\/h2>\n<p>La familia de tumores del sarcoma de ewing (esft) incluye un grupo heterog\u00e9neo de neoplasias formadas por c\u00e9lulas redondas de peque\u00f1o tama\u00f1o con m\u00ednima evidencia morfol\u00f3gica de diferenciaci\u00f3n, o por c\u00e9lulas m\u00e1s grandes con diferentes grados de diferenciaci\u00f3n neuroectod\u00e9rmica. El sarcoma de ewing es el segundo tumor \u00f3seo m\u00e1s frecuente, afectando fundamentalmente a ni\u00f1os y adolescentes. Aunque aparece preferentemente en hueso, aproximadamente un 15 % de los pacientes presentan tumores primarios en tejidos blandos.  el tratamiento actual combina dosis elevadas de agentes quimioterap\u00e9uticos para el control sist\u00e9mico de la enfermedad, con cirug\u00eda y\/o radiaci\u00f3n para el control local. A pesar del uso de terapias multimodales y medidas agresivas de control local, la supervivencia de pacientes con met\u00e1stasis es menor del 30 %, mientras que en ausencia de enfermedad metast\u00e1sica, es aproximadamente de 50-70 %. Debido a esto, son necesarias nuevas aproximaciones terap\u00e9uticas dirigidas a reducir la morbilidad relacionada con el tratamiento y a mejorar el \u00edndice de supervivencia.  afortunadamente, los esft presentan una diana molecular perfecta que resulta de la translocaci\u00f3n cromos\u00f3mica que define a este tipo de tumores, e involucra al gen ews y a un miembro de la familia de factores de transcripci\u00f3n ets (erytroblastic transforming sequence), fundamentalmente fli-1 o erg. La translocaci\u00f3n m\u00e1s com\u00fan, t(11;22)(q24;q12), genera la formaci\u00f3n de la oncoprote\u00edna de fusi\u00f3n ews\/fli-1 que act\u00faa como factor de transcripci\u00f3n y regula de forma aberrante la expresi\u00f3n de genes diana, favoreciendo de esta forma el proceso tumorig\u00e9nico.  de esta forma la inactivaci\u00f3n de la prote\u00edna de fusi\u00f3n ews\/fli-1 se convierte en una estrategia atractiva, no s\u00f3lo debido a su especificidad en c\u00e9lulas transformadas, sino tambi\u00e9n por su funci\u00f3n fundamental en la tumorig\u00e9nesis de esft. En este estudio se evaluaron diferentes estrategias dirigidas a reducir los nivel<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sarcoma de ewing: nuevas aproximaciones terapeuticas y busqueda de dianas biologicas del oncogen ews\/fli-1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sarcoma de ewing: nuevas aproximaciones terapeuticas y busqueda de dianas biologicas del oncogen ews\/fli-1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Mateo Lozano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Notario Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Ciudad g\u00f3mez <\/li>\n<li> De torres gomez-pallete carmen (vocal)<\/li>\n<li>andreu Parareda salles (vocal)<\/li>\n<li>anna Mar\u00eda Bassols teixido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Mateo Lozano La familia de tumores del sarcoma de ewing (esft) incluye un grupo heterog\u00e9neo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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