{"id":59394,"date":"2018-03-09T22:47:13","date_gmt":"2018-03-09T22:47:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-permeabilizacion-mitocondrial-en-la-muerte-neuronal\/"},"modified":"2018-03-09T22:47:13","modified_gmt":"2018-03-09T22:47:13","slug":"papel-de-la-permeabilizacion-mitocondrial-en-la-muerte-neuronal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/papel-de-la-permeabilizacion-mitocondrial-en-la-muerte-neuronal\/","title":{"rendered":"Papel de la permeabilizaci\u00f3n mitocondrial en la muerte neuronal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Daniel Tornero Prieto <\/strong><\/h2>\n<p>La permeabilizaci\u00f3n de las membranas mitocondriales es un proceso considerado como punto de no retorno en las v\u00edas de se\u00f1alizaci\u00f3n apopt\u00f3tica responsables de gran cantidad de patolog\u00edas que afectan de manera particular al sistema nervioso como la isquemia, el envejecimiento y algunas enfermedades neurodegenerativas. En este trabajo se estudian procesos que tienen lugar durante la permeabilizaci\u00f3n de la membrana interna mitocondrial en respuesta a dos est\u00edmulos como son el aumento en los niveles de calcio intracelular y la acumulaci\u00f3n de especies reactivas del ox\u00edgeno, responsables del denominado estr\u00e9s oxidativo. A trav\u00e9s de t\u00e9cnicas electrofisiol\u00f3gicas, microfluorim\u00e9tricas y bioqu\u00edmicas se estudian procesos como la activaci\u00f3n del canal de multiple conductancia, la p\u00e9rdida del potencial mitocondrial, el hinchamiento de la matriz mitocondrial, la liberaci\u00f3n de citocromo c hasta el citoplasma y la activaci\u00f3n de la cascada de las caspasas. Adem\u00e1s, se estudi\u00f3 el papel de la prote\u00edna anti-apopt\u00f3tica de la familia de bcl-2, bcl-xl, en la regulaci\u00f3n de estos procesos, demostr\u00e1ndose su funci\u00f3n inhibitoria de esta prote\u00edna mitocondrial sobre los mismos. Por \u00faltimo, se comprob\u00f3 el da\u00f1o causado por las especies reactivas del ox\u00edgeno sobre la actividad de dos enzimas esenciales del metabolismo energ\u00e9tico celular, como son la gliceraldeh\u00eddo 3-fosfato deshidrogenasa y la citrato sintetasa.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la permeabilizaci\u00f3n mitocondrial en la muerte neuronal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la permeabilizaci\u00f3n mitocondrial en la muerte neuronal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Daniel Tornero Prieto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Castilla-la mancha<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Valent\u00edn Ce\u00f1a Callejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Belmonte mart\u00ednez <\/li>\n<li>Mar\u00eda  isabel Loza garcia (vocal)<\/li>\n<li>arcadio Gual sala (vocal)<\/li>\n<li>Francisco Zaragoza garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Daniel Tornero Prieto La permeabilizaci\u00f3n de las membranas mitocondriales es un proceso considerado como punto de no [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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