{"id":59401,"date":"2018-03-09T22:47:13","date_gmt":"2018-03-09T22:47:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aggregatibacter-actinomycetemcomitans-su-susceptibilidad-a-los-antimicrobianos\/"},"modified":"2018-03-09T22:47:13","modified_gmt":"2018-03-09T22:47:13","slug":"aggregatibacter-actinomycetemcomitans-su-susceptibilidad-a-los-antimicrobianos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/microbiologia-clinica\/aggregatibacter-actinomycetemcomitans-su-susceptibilidad-a-los-antimicrobianos\/","title":{"rendered":"Aggregatibacter actinomycetemcomitans: su susceptibilidad a los antimicrobianos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> C\u00e9sar Escribano Pat\u00f3n <\/strong><\/h2>\n<p>Aggregatibacter actinomycetemcomitans es una bacteria gram negativa anaerobia facultativa, de morfolog\u00eda bacilar o coco-bacilar, frecuentemente asociada a procesos patol\u00f3gicos de la cavidad bucal como la gingivitis, la periodonitis juvenil o la periodontitis progresiva aguda. El papel de su membrana externa en la resistencia a los antibi\u00f3ticos de uso com\u00fan en odontolog\u00eda se conoce poco.     en nuestro trabajo, hemos procedido al aislamiento e identificaci\u00f3n de una serie de cepas de a.Acetinomycetemcomitans procedentes de muestras cl\u00ednicas de casos especialmente graves de priodontitis agrevisas y menos agresivas, que hemos comparado con dos cepas referencia de laboratorio. Hemos comprobado como tanto los patrones de suscpetibilidad antibi\u00f3tica frente a antibi\u00f3ticos de uso com\u00fan en dontolog\u00eda, como los perfiles de prote\u00ednas de externa estudiados mediante electroforesis en geles desnaturalizantes de acrilamida (sds-page), no var\u00edan significativamente entre unas cepas y otras, no presentando la variabilidad esperada.     una de las prote\u00ednas de membrana externa presente en todas las cepas, la denominada seg\u00fan su peso molecular como omp 39, cumple la mayor\u00eda de las condicones que presentan las porinas, habi\u00e9ndose puesto de manifiesto su actividad formadora de poro mediante experimentos en planar lipid bilayer, en los que muestra una conductancia de 0,75ns en kcl 1m y un tama\u00f1o de poro de alrededor de 0.73 nm.     la presencia de una \u00fanica peque\u00f1a porina en la pared celular de aggregatibacter actinomycetemcomitans, unido a la ausencia de otros mecanismos de resistencia comunes como la existencia de integrones con genes de resistencia, podr\u00eda condicionar su demostrada resistencia a ciertos tipos de antibi\u00f3ticos.     adem\u00e1s, se ha demostrado la presencia funcional de una bomba de reflujo tipo acrab, inhibible por cccp, habi\u00e9ndose detectado por amplificaci\u00f3n la presencia de los genes que la codifican. La presencia de dicho arsenal gen\u00e9tico n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aggregatibacter actinomycetemcomitans: su susceptibilidad a los antimicrobianos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aggregatibacter actinomycetemcomitans: su susceptibilidad a los antimicrobianos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 C\u00e9sar Escribano Pat\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Vi\u00f1as Ciordia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Pedro Martinez Garcia <\/li>\n<li>M\u00aa Teresa Jim\u00e9nez De Anta (vocal)<\/li>\n<li>Anna Fenosa Bernad\u00f3 (vocal)<\/li>\n<li>Tom\u00e1s Gonz\u00e1lez Villa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de C\u00e9sar Escribano Pat\u00f3n Aggregatibacter actinomycetemcomitans es una bacteria gram negativa anaerobia facultativa, de morfolog\u00eda bacilar o coco-bacilar, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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