{"id":59437,"date":"2018-03-09T22:47:17","date_gmt":"2018-03-09T22:47:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-de-la-inflamacion-en-la-lesion-renal-secundaria-a-la-diabetes-mellitus\/"},"modified":"2018-03-09T22:47:17","modified_gmt":"2018-03-09T22:47:17","slug":"implicaciones-de-la-inflamacion-en-la-lesion-renal-secundaria-a-la-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-de-la-inflamacion-en-la-lesion-renal-secundaria-a-la-diabetes-mellitus\/","title":{"rendered":"Implicaciones de la inflamaci\u00f3n en la lesi\u00f3n renal secundaria a la diabetes mellitus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Francisco Navarro Gonz\u00e1lez <\/strong><\/h2>\n<p>La diabetes mellitus se ha constituido en un gran problema de salud p\u00fablica.  Es una de las enfermedades con mayor preValencia, asociando complicaciones de gran trascendencia, con consecuencias devastadoras desde el punto de vista cl\u00ednico, social y econ\u00f3mico. Dentro de las complicaciones de la diabetes destaca la afectaci\u00f3n renal, la nefropat\u00eda diab\u00e9tica (nd). Esta complicaci\u00f3n se ha convertido en la primera causa de insuficiencia renal y de entrada en programas de tratamiento sustitutivo de la funci\u00f3n renal. Junto a ello, el desarrollo de nd se asocia a un dram\u00e1tico incremento del riesgo cardiovascular. en la \u00faltima d\u00e9cada hemos asistido a un cambio en las consideraciones patog\u00e9nicas de la diabetes mellitus, de forma que hoy en d\u00eda existe un importante cuerpo de evidencia sobre el importante papel de la activaci\u00f3n de la inmunidad innata, y el subsecuente desarrollo de una reacci\u00f3n inflamatoria cr\u00f3nica de bajo grado, en la aparici\u00f3n de la enfermedad. Por otra parte, tambi\u00e9n se ha se\u00f1alado el papel de este fen\u00f3meno inflamatorio en el desarrollo de las complicaciones de la diabetes, como la retinopat\u00eda o la neuropat\u00eda diab\u00e9tica. El objetivo de los estudios que conforman esta tesis ha sido analizar el papel de la inflamaci\u00f3n en la lesi\u00f3n renal secundaria a la diabetes mellitus desde tres perspectivas: 1) cl\u00ednica, estudiando la relaci\u00f3n entre el factor de necrosis tumoral-alfa (tnfa), una de las principales citoquinas pro-inflamatorias, y marcadores cl\u00ednicos de da\u00f1o renal en el paciente diab\u00e9tico (excreci\u00f3n urinaria de alb\u00famina y de n-acetil-b-glucosaminidasa (nag); 2) en un modelo animal de nefropat\u00eda diab\u00e9tica, analizando la expresi\u00f3n renal de las principales citoquinas pro-inflamatorias (interleukina-1, interleukina-6 y tnfa), estudiando su relaci\u00f3n con par\u00e1metros de da\u00f1o renal, y evaluando el efecto de la administraci\u00f3n de pentoxifilina, una sustancia con propiedades anti-tnfa; y 3) traslacional, analizando en el paciente diab<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones de la inflamaci\u00f3n en la lesi\u00f3n renal secundaria a la diabetes mellitus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones de la inflamaci\u00f3n en la lesi\u00f3n renal secundaria a la diabetes mellitus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Francisco Navarro Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Armando Torres Ram\u00edrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Hern\u00e1ndez nieto <\/li>\n<li>Jos\u00e9 Carlos Rodriguez perez (vocal)<\/li>\n<li> Mart\u00edn de Francisco hern\u00e1ndez angel Luis (vocal)<\/li>\n<li>Alberto Mart\u00ednez castelao (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Francisco Navarro Gonz\u00e1lez La diabetes mellitus se ha constituido en un gran problema de salud p\u00fablica. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,9915],"tags":[72309,10010,58078,131329,9971,70377],"class_list":["post-59437","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-la-laguna","tag-alberto-Martinez-castelao","tag-armando-torres-ramirez","tag-jose-carlos-rodriguez-perez","tag-juan-francisco-navarro-gonzalez","tag-luis-hernandez-nieto","tag-martin-de-francisco-hernandez-angel-luis"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59437"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59437\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}