{"id":59440,"date":"2018-03-09T22:47:17","date_gmt":"2018-03-09T22:47:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-del-gen-apob-y-produccion-de-vldl-durante-la-sepsis-experimental-inducida-por-bacterias-gram-negativas\/"},"modified":"2018-03-09T22:47:17","modified_gmt":"2018-03-09T22:47:17","slug":"expresion-del-gen-apob-y-produccion-de-vldl-durante-la-sepsis-experimental-inducida-por-bacterias-gram-negativas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/expresion-del-gen-apob-y-produccion-de-vldl-durante-la-sepsis-experimental-inducida-por-bacterias-gram-negativas\/","title":{"rendered":"Expresi\u00f3n del gen apob y producci\u00f3n de vldl durante la sepsis experimental inducida por bacterias gram-negativas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Nerea Bartolome Escobar <\/strong><\/h2>\n<p>La sepsis es actualmente la primera causa de muerte en pacientes hospitalizados. La hipertrigliceridemia, vinculada a vldl, es una de las principales alteraciones metab\u00f3licas asociadas a las pepticemia y se ha propuesto que forma parte de la respuesta inmunol\u00f3gica de fase aguda. sin embargo, su etiolog\u00eda y significado no se conocen con precisi\u00f3n. la presente tesis tiene como principal objetivo evaluar potenciales mecanismos y mediadores implicados en la elevada producci\u00f3n de vldl durante el curso de las spesis experimental inducida por bacterias gram-negativas en ratas. Se encuentra que existen dos fases en la respuesta metab\u00f3lica asociada a la spesis temprana 24h, con diferentes mecanismos que podr\u00edan favorecer la mayor secreci\u00f3n de hep\u00e1tica de vldl. En la fase inicial, cuando se detecta la mayor hipertrilgiceridemia, una mayor disponibilidad de ag circulantes y un aumento en la actividad mtp hep\u00e1tica podr\u00edan propiciar la mayor secreci\u00f3n de part\u00edculas de vldl y tg asociados a ellas. en cambio, en la segunda fase la secreci\u00f3n de vldl estar\u00eda promovida por el incremento en el contenido hep\u00e1tico del mrna de apob, detectado en 24h, lo que indica que la regulaci\u00f3n de la expresi\u00f3n de la apb no es estrictamente postrduccional. Aunque la tasa de transcripci\u00f3n total en el h\u00edgado aumenta a 16h de la inducci\u00f3n de la sepsis, no hay una mayor transcripci\u00f3n del gen apob, en cambio, s\u00ed aumenta en 24h la formaci\u00f3n de complejos entre el mrna de apob y prote\u00ednas hur, lo que sugiere una mayor estabilidad del transcrito y explicar\u00eda el aumento en su contenido hep\u00e1tico en este tiempo. En la sepsis, el conjunto de los efectores liberados pro las c\u00e9lulas de kupffer podr\u00eda mediar directamente el incremento den la secrecci\u00f3n hep\u00e1tica de vldl, ya que el conjunto de efectores secretados por c\u00e9lulas de kupffer en cultivo estimuladas con lps aumenta la secreci\u00f3n de apob y l\u00edpidos de vldl por hepatociso en cultivo. Las citoquinas tnf-alfa, il-6 e il-1beta, p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n del gen apob y producci\u00f3n de vldl durante la sepsis experimental inducida por bacterias gram-negativas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n del gen apob y producci\u00f3n de vldl durante la sepsis experimental inducida por bacterias gram-negativas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Nerea Bartolome Escobar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Yolanda Chico Carmona<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Casis s\u00e1enz <\/li>\n<li>gorka Base\u00f1ez asua (vocal)<\/li>\n<li>Jos\u00e9 Juan Garcia marin (vocal)<\/li>\n<li>jordi Muntan\u00e9 relat (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Nerea Bartolome Escobar La sepsis es actualmente la primera causa de muerte en pacientes hospitalizados. La hipertrigliceridemia, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,964,12909],"tags":[131336,51078,1109,13402,131335,60544],"class_list":["post-59440","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-lipidos","category-pais-vasco-euskal-herriko-unibertsitatea","tag-gorka-basenez-asua","tag-jordi-muntane-relat","tag-jose-juan-garcia-marin","tag-luis-casis-saenz","tag-nerea-bartolome-escobar","tag-yolanda-chico-carmona"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59440","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59440"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59440\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}