{"id":59494,"date":"2018-03-09T22:47:21","date_gmt":"2018-03-09T22:47:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-2-metoxiestradiol-en-el-remodelado-vascular-inducido-por-la-hipertension\/"},"modified":"2018-03-09T22:47:21","modified_gmt":"2018-03-09T22:47:21","slug":"efecto-del-2-metoxiestradiol-en-el-remodelado-vascular-inducido-por-la-hipertension","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-2-metoxiestradiol-en-el-remodelado-vascular-inducido-por-la-hipertension\/","title":{"rendered":"Efecto del 2-metoxiestradiol en el remodelado vascular inducido por la hipertensi\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> B\u00e1rbara Bonacasa Fern\u00e1ndez <\/strong><\/h2>\n<p>Objetivo     estudiar el efecto del tratamiento con 2-metoxiestradiol en el remodelado vascular mioc\u00e1rdico inducido por la hipertensi\u00f3n y tras una lesi\u00f3n vascular por denudaci\u00f3n endotelial en arterial formal.  material y m\u00e9todos modelo de hipertensi\u00f3n     se han utilizado 5 grupos experimentales de ratas shr de 10 semanas de vida: ratas hembra intactas, ratas hembras ovariectomizadas, ratas hembra ovariectomizadas y tratadas con 2-metoxiestradiol, ratas macho y ratas macho tratadas con 2-metoxiestradiol. Se les midi\u00f3 la presi\u00f3n por plestimograf\u00eda una vez por semana hasta la semana 18. En la semana 18 se les extrae el coraz\u00f3n y los vasos de lecho mesent\u00e9rico para realizar los protocolos de laboratorio de an\u00e1lisis de la estructura vascular mioc\u00e1rdica y de medici\u00f3n del estr\u00e9s oxidativo y expresi\u00f3n de prote\u00ednas relacionadas con la proliferaci\u00f3n celular.  modelo de lesi\u00f3n vascular por denudaci\u00f3n endotelial en arteria femoral     se han utilizado 5 grupos experimentales de ratas sd: hembras intactas, hembras ovariectomizdas, hembra sovariectomizadas y tratadas con 2-metoxiestradiol, ratas macho y ratas macho tratados con 2-metoxiestradiol. A la semana de establecer los grupos se realiza la cirug\u00eda de denudaci\u00f3n endotelial en la arteria fermola y a las 2 semanas se extraer la muestra y se analiza la formaic\u00f3n de neo\u00edntima en el vaso.  resultados modelo de hipertensi\u00f3n     existen diferencias entre sexos en la ratas shr, tanto en la evoluci\u00f3n de la hipertensi\u00f3n durante las 8 semanas de observaci\u00f3n, como en el remodelado vascular mioc\u00e1rdico, en la actividad de la nadph oxidasa vascular de lecho mesent\u00e9rico como en la expresi\u00f3n de factores de proliferaci\u00f3n celular en la semana 18. el tratamiento con 2-metoxiestradiol atenu\u00f3 el aumento de la presi\u00f3n arterial sist\u00f3lica que provoc\u00f3 la ovariectom\u00eda, as\u00ed como en el remodelado vascular mioc\u00e1rdico, en la actividad de la nadph oxidasa y la expresi\u00f3n de prote\u00ednas en el lecho me<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del 2-metoxiestradiol en el remodelado vascular inducido por la hipertensi\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del 2-metoxiestradiol en el remodelado vascular inducido por la hipertensi\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 B\u00e1rbara Bonacasa Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Hernandez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda no Vald\u00e9s ch\u00e1varri <\/li>\n<li> Pallard\u00f3 calatayud federico vicente (vocal)<\/li>\n<li>Juan  Jos\u00e9 Parrilla paricio (vocal)<\/li>\n<li>Antonio Alberola aguilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de B\u00e1rbara Bonacasa Fern\u00e1ndez Objetivo estudiar el efecto del tratamiento con 2-metoxiestradiol en el remodelado vascular mioc\u00e1rdico inducido [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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