{"id":59503,"date":"2018-03-09T22:47:21","date_gmt":"2018-03-09T22:47:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-dano-neuroaxonal-en-esclerosis-multiple-precoz-mediante-espectroscopia-de-proton-del-troncoencefalo-un-estudio-prospectivo-a-dos-anos\/"},"modified":"2018-03-09T22:47:21","modified_gmt":"2018-03-09T22:47:21","slug":"estudio-del-dano-neuroaxonal-en-esclerosis-multiple-precoz-mediante-espectroscopia-de-proton-del-troncoencefalo-un-estudio-prospectivo-a-dos-anos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/medicina-interna\/estudio-del-dano-neuroaxonal-en-esclerosis-multiple-precoz-mediante-espectroscopia-de-proton-del-troncoencefalo-un-estudio-prospectivo-a-dos-anos\/","title":{"rendered":"Estudio del da\u00f1o neuroaxonal en esclerosis m\u00faltiple precoz mediante espectroscopia de prot\u00f3n del troncoenc\u00e9falo: un estudio prospectivo a dos a\u00f1os"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pascual Lozano Ana Mar\u00eda <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple es una enfermedad inflamatoria desmielinizante del sistema nervioso central en cuya fisiopatogenia ha sido implicada adem\u00e1s una degeneraci\u00f3n neuroaxonal de car\u00e1cter progresivo y origen desconocido, directamente relacionada con el ac\u00famulo de discapacidad en las formas progresivas de la enfermedad. Sin embargo, recientes estudios, patol\u00f3gicos y de resonancia magn\u00e9tica no convencional ya hab\u00edan apuntado que el comienzo de este proceso neurodegenerativo podr\u00eda tener lugar en fases precoces de la enfermedad, si bien el tipo de relaci\u00f3n existente entre las alteraciones de origen inflamatorio y la afectaci\u00f3n axonal, fuera de las lesiones agudas, no habr\u00eda podido ser convenientemente  demostrado. la hip\u00f3tesis que exploraba este trabajo de investigaci\u00f3n era la presencia de da\u00f1o neuroaxonal, cuantificable por resonancia magn\u00e9tica espectrosc\u00f3pica, en la sustancia blanca aparentemente normal del troncoenc\u00e9falo, en un grupo de pacientes con esclerosis m\u00faltiple, en su forma remitente-recurrente y con un tiempo corto de evoluci\u00f3n.  Seleccionamos el troncoenc\u00e9falo con la finalidad de aumentar la sensibilidad de la t\u00e9cnica a cambios metab\u00f3licos precoces, en tanto que gran n\u00famero de haces neuronales ascienden y descienden a lo largo del tronco cerebral. Se trata de un estudio longitudinal, prospectivo a dos a\u00f1os, en el que comparamos las variaciones de n-acetilaspartato, creatina y colina (metabolitos cerebrales), entre 43 pacientes de esclerosis m\u00faltiple y 10 sujetos sanos. Los metabolitos se calcularon mediante el programa jmrui, sobre cuatro vol\u00famenes de inter\u00e9s representativos del troncoenc\u00e9falo. En el grupo de pacientes calculamos adem\u00e1s las variaciones de la carga lesional en secuencia potenciada en t2, anualmente. En el estudio basal ya obtuvimos una p\u00e9rdida de axones, representada por el descenso del cociente n-acetilaspartato\/colina, en el grupo de pacientes frente a los controles. Mientras que los controles no sufrieron<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del da\u00f1o neuroaxonal en esclerosis m\u00faltiple precoz mediante espectroscopia de prot\u00f3n del troncoenc\u00e9falo: un estudio prospectivo a dos a\u00f1os<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del da\u00f1o neuroaxonal en esclerosis m\u00faltiple precoz mediante espectroscopia de prot\u00f3n del troncoenc\u00e9falo: un estudio prospectivo a dos a\u00f1os <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pascual Lozano Ana Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Bonaventura Casanova Estruch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 angel Berciano blanco <\/li>\n<li>Jos\u00e9 vicente Manj\u00f3n herrera (vocal)<\/li>\n<li>sebasti\u00e1n Cerd\u00e1n Garc\u00eda-esteller (vocal)<\/li>\n<li>Jaime Gili planas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pascual Lozano Ana Mar\u00eda La esclerosis m\u00faltiple es una enfermedad inflamatoria desmielinizante del sistema nervioso central en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[139,1880],"tags":[131469,31708,11565,116732,131468,39708],"class_list":["post-59503","post","type-post","status-publish","format-standard","hentry","category-medicina-interna","category-neurologia","tag-bonaventura-casanova-estruch","tag-jaime-gili-planas","tag-jose-angel-berciano-blanco","tag-jose-vicente-manjon-herrera","tag-pascual-lozano-ana-maria","tag-sebastian-cerdan-garcia-esteller"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59503","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59503"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59503\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59503"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59503"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59503"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}