{"id":59554,"date":"2018-03-09T22:47:25","date_gmt":"2018-03-09T22:47:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-de-acido-micofenolico-en-pacientes-con-trasplante-renal-y-trasplante-de-celulas-progenitoras-hematopoyeticas\/"},"modified":"2018-03-09T22:47:25","modified_gmt":"2018-03-09T22:47:25","slug":"monitorizacion-de-acido-micofenolico-en-pacientes-con-trasplante-renal-y-trasplante-de-celulas-progenitoras-hematopoyeticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/monitorizacion-de-acido-micofenolico-en-pacientes-con-trasplante-renal-y-trasplante-de-celulas-progenitoras-hematopoyeticas\/","title":{"rendered":"Monitorizaci\u00f3n de acido micofen\u00f3lico en pacientes con trasplante renal y trasplante de c\u00e9lulas progenitoras hematopoy\u00e9ticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Noemi Rebollo Diaz <\/strong><\/h2>\n<p>El trasplante renal es el tratamiento de elecci\u00f3n en la \u00faltima fase de la insuficiencia renal terminal. En los \u00faltimos 10 a\u00f1os ha aumentado la eficacia de este tratamiento debido a los importantes cambios en la pr\u00e1ctica cl\u00ednica del trasplante y en las estrategias inmunosupresoras. A esto \u00faltimo ha contribuido la optiniizaci\u00f3n de los regimenes de dosificaci\u00f3n, consiguiendo suficiente inmunosupresi\u00f3n para el mantenimiento del \u00f3rgano con el m\u00ednimo riesgo de infecciones y efectos adversos. Una herramienta actualmente imprescindible en la dosificaci\u00f3n de inmuno supresores es la monitorizaci\u00f3n terap\u00e9utica de sus concentraciones.  la monitorizaci\u00f3n de f\u00e1rmacos inmunosupresores presenta especial inter\u00e9s debido a la complejidad de los protocolos de inmunosupresi\u00f3n y a la necesidad de corregir las dosis en funci\u00f3n de la evoluci\u00f3n del paciente y del \u00f3rgano trasplantado.  diferentes estudios multic\u00e9ntricos han demostrado que el micofenolato de mofetio (mmf) reduce la incidencia y severidad de los episodios de rechazo agudo, prolonga la supervivencia del injerto y del paciente, mejora la funci\u00f3n del injerto, se tolera mejor y presenta menor incidencia de efectos adversos que otros inmuno supresores.  aunque hace menos de 10 a\u00f1os que se aprob\u00f3 su utilizaci\u00f3n por la fda, el mmf est\u00e1 presente en la mayor\u00eda de protocolos de inmunosupresi\u00f3n de trasplantes s\u00f3lidos. Esto ha despertado un gran inter\u00e9s en la monitorizaci\u00f3n de sus tratamientos, existiendo la necesidad de que se aporten datos sobre la farmacocin\u00e9tica y farmacodinamia del \u00e1cido micofen\u00f3lieo (mpa), metabolito al que debe su actividad el mmif, que sirvan como gu\u00edas para la optirnizaci\u00f3n de los reg\u00edmenes de dosificaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizaci\u00f3n de acido micofen\u00f3lico en pacientes con trasplante renal y trasplante de c\u00e9lulas progenitoras hematopoy\u00e9ticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizaci\u00f3n de acido micofen\u00f3lico en pacientes con trasplante renal y trasplante de c\u00e9lulas progenitoras hematopoy\u00e9ticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Noemi Rebollo Diaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Victoria Calvo Hernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 mat\u00edas Tabernero romo <\/li>\n<li>Jos\u00e9 Mar\u00eda Morales  cerdan (vocal)<\/li>\n<li>Jos\u00e9 Luis Poveda andres (vocal)<\/li>\n<li>Mar\u00eda  dolores Aumente rubio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Noemi Rebollo Diaz El trasplante renal es el tratamiento de elecci\u00f3n en la \u00faltima fase de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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