{"id":59561,"date":"2018-03-09T22:47:25","date_gmt":"2018-03-09T22:47:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-colestasis-materna-y-del-tratamiento-con-acido-ursodesoxicolico-sobre-el-estres-oxidativo-y-los-sistemas-de-defensa-antioxidante-en-placenta-e-ha%c2%adgado-fetal\/"},"modified":"2018-03-09T22:47:25","modified_gmt":"2018-03-09T22:47:25","slug":"efecto-de-la-colestasis-materna-y-del-tratamiento-con-acido-ursodesoxicolico-sobre-el-estres-oxidativo-y-los-sistemas-de-defensa-antioxidante-en-placenta-e-ha%c2%adgado-fetal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisiologia-humana\/efecto-de-la-colestasis-materna-y-del-tratamiento-con-acido-ursodesoxicolico-sobre-el-estres-oxidativo-y-los-sistemas-de-defensa-antioxidante-en-placenta-e-ha%c2%adgado-fetal\/","title":{"rendered":"Efecto de la colestasis materna y del tratamiento con \u00e1cido ursodesoxic\u00f3lico sobre el estr\u00e9s oxidativo y los sistemas de defensa antioxidante en placenta e h\u00edgado fetal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Casta\u00f1o Rodriguez <\/strong><\/h2>\n<p>Antecedentes: la colestasis materna durante el embarazo se ha asociado con da\u00f1o y alteraci\u00f3n en la funci\u00f3n del h\u00edgado materno y en el de sus neonatos. Sin embargo, se desconocen sus repercusiones sobre h\u00edgado fetal y placenta. Objetivo: analizar la presencia de estr\u00e9s oxidativo y apoptosis y la respuesta del sistema de defensa antioxidante frente a la hipercolanemia e hiperbilirrubinemia asociadas a la colestasis gestacional y al tratamiento con \u00e1cido ursodesoxic\u00f3lico (audc), melatonina (mel) o silimarina (sil) en h\u00edgado adulto, placenta e h\u00edgado fetal. M\u00e9todos: como modelo in vivo se utiliz\u00f3 la obstrucci\u00f3n del conducto biliar en ratas gestantes desde el d\u00eda 14 al 21 de gestaci\u00f3n. Algunos grupos recibieron diariamente v\u00eda i.G. Mel, sil o audc. Como modelo in vitro se utilizaron l\u00edneas celulares humanas de hepatoblastoma (hepg2) y coriocarcinoma (jar) incubadas con \u00e1cido tauroc\u00f3lico (atc), audc o br. Resultados: la colestasis obstructiva provoc\u00f3 da\u00f1o oxidativo y un desequilibrio del sistema antioxidante en h\u00edgado materno, placenta e h\u00edgado fetal, acompa\u00f1ado de una activaci\u00f3n de la apoptosis por la v\u00eda mitocondrial. El tratamiento con audc, mel y sil previno parcialmente el da\u00f1o oxidativo y la apoptosis en los tres \u00f3rganos, reduciendo su exposici\u00f3n a los \u00e1cidos biliares m\u00e1s t\u00f3xicos, restableciendo los niveles de glutati\u00f3n y corrigiendo el desequilibrio proapopt\u00f3tico. El audc y la mel estimularon la expresi\u00f3n g\u00e9nica de la biliverdina reductasa (bvr) y los transportadores de vitamina c, svct1 y svct2. La br increment\u00f3 los niveles de arnm de bvr, svct1 y svct2 en c\u00e9lulas hepg2 y jar. El audc y el atc estimularon la expresi\u00f3n de bvr y svct2 en ambas l\u00edneas celulares, y la de svct1 s\u00f3lo en las jar. Conclusiones: la colestasis materna en ratas induce estr\u00e9s oxidativo y apoptosis en placenta e h\u00edgado fetal, que se previene con el tratamiento con audc, mel o sil.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la colestasis materna y del tratamiento con \u00e1cido ursodesoxic\u00f3lico sobre el estr\u00e9s oxidativo y los sistemas de defensa antioxidante en placenta e h\u00edgado fetal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la colestasis materna y del tratamiento con \u00e1cido ursodesoxic\u00f3lico sobre el estr\u00e9s oxidativo y los sistemas de defensa antioxidante en placenta e h\u00edgado fetal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Casta\u00f1o Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 30\/06\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa. Jose Perez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  angeles Serrano garcia <\/li>\n<li>montserrat Mari garcia (vocal)<\/li>\n<li>angel Fernando Porteros herrero (vocal)<\/li>\n<li>Mar\u00eda  dolores Suarez ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Casta\u00f1o Rodriguez Antecedentes: la colestasis materna durante el embarazo se ha asociado con da\u00f1o y alteraci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[957,817,9386],"tags":[131593,131592,39355,3372,121214,100872],"class_list":["post-59561","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-fisiologia-humana","category-salamanca","tag-angel-fernando-porteros-herrero","tag-beatriz-castano-rodriguez","tag-maria-angeles-serrano-garcia","tag-maria-dolores-suarez-ortega","tag-montserrat-mari-garcia","tag-ma-jose-perez-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59561"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59561\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59561"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59561"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}