{"id":59598,"date":"2007-03-07T00:00:00","date_gmt":"2007-03-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-las-variaciones-en-los-loci-geneticos-de-las-apolipoproteinas-ai-ciii-aiv-b-e-y-de-la-lipasa-hepatica-sobre-la-susceptibilidad-a-la-oxidacion-de-las-ldl\/"},"modified":"2007-03-07T00:00:00","modified_gmt":"2007-03-07T00:00:00","slug":"efecto-de-las-variaciones-en-los-loci-geneticos-de-las-apolipoproteinas-ai-ciii-aiv-b-e-y-de-la-lipasa-hepatica-sobre-la-susceptibilidad-a-la-oxidacion-de-las-ldl","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-molecular\/efecto-de-las-variaciones-en-los-loci-geneticos-de-las-apolipoproteinas-ai-ciii-aiv-b-e-y-de-la-lipasa-hepatica-sobre-la-susceptibilidad-a-la-oxidacion-de-las-ldl\/","title":{"rendered":"Efecto de las variaciones en los loci geneticos de las apolipoproteinas ai, ciii, aiv, b e y de la lipasa hepatica sobre la susceptibilidad a la oxidaci\u00f3n de las ldl"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Purificacion Gomez Luna <\/strong><\/h2>\n<p>Objetivos     determinar si los polimorfismos presentes en el gen de la apo c-iii, determinan un menor tama\u00f1o y una mayor oxidabilidad de las part\u00edculas ldl, analizando los cambios que, sobre estos par\u00e1metros, inducen las dietas con distintos contenidos y calidad de grasa.  determinar si en una poblaci\u00f3n sana, existen variaciones gen\u00e9ticas en los loci de las apolipoprote\u00ednas, a-i, a-iv, b y lipasa hep\u00e1tica, que determinen una mayor oxidabilidad de las lipoprote\u00ednas. Examinar si la dieta mediterr\u00e1nea disminuye la susceptibilidad a la oxidaci\u00f3n de las ldl en subgrupos de poblaci\u00f3n definidos por los marcadores gen\u00e9ticos anteriormente descritos. Determinar si en la poblaci\u00f3n general existen variaciones gen\u00e9ticas que condicionen el tama\u00f1o de las  ldl dentro de los loci de la apolilpoproteinas a-i, a-iv, b, y lipasa hep\u00e1tica como condicionante de la susceptibilidad a la oxidaci\u00f3n de las ldl.   personas, dise\u00f1o y metodolog\u00eda     97 voluntarios sanos recibieron una dieta de estabilizaci\u00f3n de cuatro semanas rica en grasa saturada y tras \u00e9sta se administr\u00f3, de forma aleatorizada y cruzada, una alimentaci\u00f3n t\u00edpica mediterr\u00e1nea rica en grasa monoinsaturada y otra pobre en casa, y rica en hidratos de carbono. Al final de cada periodo diet\u00e9tico se determinaron los niveles de l\u00edpidos y se aislaron las lipoproteinas mediante ultracentrifugaci\u00f3n en gradiente de densidad. Las ldl obtenidas se sometieron a un proceso de oxidaci\u00f3n promovida por cobre. El tama\u00f1o de las ldl se determin\u00f3 por electroforesis en geles de poliacrilamida en gradiente del 2-16%.  resultados     el tama\u00f1o y la resistencia a la oxidaci\u00f3n de las ldl eran inferiores en los homocigotos para el alelo c del polimorfismo c-482t del gen de la apo c-iii tras la dieta mediterr\u00e1nea. Los portadores del alelo a del gen de la apo a-i mostraron menor tama\u00f1o y menor tiempo de latencia en la oxidaci\u00f3n que los homocigotos  para el alelo g. Los homocigotos para el alelo gln360 del gen<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de las variaciones en los loci geneticos de las apolipoproteinas ai, ciii, aiv, b e y de la lipasa hepatica sobre la susceptibilidad a la oxidaci\u00f3n de las ldl<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de las variaciones en los loci geneticos de las apolipoproteinas ai, ciii, aiv, b e y de la lipasa hepatica sobre la susceptibilidad a la oxidaci\u00f3n de las ldl <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Purificacion Gomez Luna <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Perez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Lopez miranda <\/li>\n<li>Juan  Antonio Moreno gutierrez (vocal)<\/li>\n<li>Francisco Jos\u00e9 Fuentes  jimenez (vocal)<\/li>\n<li>Francisco j. Tinahones madue\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Purificacion Gomez Luna Objetivos determinar si los polimorfismos presentes en el gen de la apo c-iii, determinan [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[115,973,964,1176],"tags":[75340,101322,1613,29545,131665,131664],"class_list":["post-59598","post","type-post","status-publish","format-standard","hentry","category-bioquimica-molecular","category-cordoba","category-lipidos","category-nutrientes","tag-francisco-j-tinahones-madueno","tag-francisco-jose-fuentes-jimenez","tag-francisco-perez-jimenez","tag-jose-lopez-miranda","tag-juan-antonio-moreno-gutierrez","tag-purificacion-gomez-luna"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59598"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59598\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}