{"id":59621,"date":"2007-04-07T00:00:00","date_gmt":"2007-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-oxidativo-y-muerte-celular-en-la-ictericia-obstructiva-experimental-efecto-de-la-melatonina-y-s-adenosil-metionina\/"},"modified":"2007-04-07T00:00:00","modified_gmt":"2007-04-07T00:00:00","slug":"estres-oxidativo-y-muerte-celular-en-la-ictericia-obstructiva-experimental-efecto-de-la-melatonina-y-s-adenosil-metionina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/estres-oxidativo-y-muerte-celular-en-la-ictericia-obstructiva-experimental-efecto-de-la-melatonina-y-s-adenosil-metionina\/","title":{"rendered":"Estr\u00e9s oxidativo y muerte celular en la ictericia obstructiva experimental. efecto de la melatonina y s-adenosil-metionina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luz Mar\u00eda Ramirez Ortiz <\/strong><\/h2>\n<p>Introducci\u00f3n     existe evidencia en la literatura de que los radicales libres del ox\u00edgeno est\u00e1n relacionados con el da\u00f1o celular hep\u00e1tico en la obstrucci\u00f3n biliar y recientes estudios han demostrado que diversos antioxidante disminuyen el da\u00f1o oxidativo en modelos de colestasis aguda. En base a ello, los antioxidantes podr\u00edan disminuir par\u00e1metros de muerte celular en el h\u00edgado al limitar el estr\u00e9s oxidativo.  objetivo     comparar el efecto de la melatonina y s-adenosilmetionina (sam) sobre par\u00e1metros de estr\u00e9s oxidativo y muerte celular en la obstrucci\u00f3n biliar experimental.  material y m\u00e9todo     la colestasis se realiz\u00f3 con un modelo de ligadura y secci\u00f3n del conducto biliar principal en ratas wistar. Tanto la melatonina como la sam se administraron por v\u00eda intraperitoneal (500 ug\/kg\/d\u00eda respectivamente) desde el d\u00eda siguiente a la ligadura biliar y durante siete d\u00edas. Se determinaron par\u00e1metros  de estr\u00e9s oxidativo en h\u00edgado y suero: lipoper\u00f3xidos (mda), glutation reducido (gsh) y enzimas antioxidantes (super\u00f3xido dismutasa, catalasa y glutati\u00f3n peroxidasa). La necrosis hep\u00e1tica fue valorada mediante bioqu\u00edmica s\u00e9rica (ast, alt) y la apoptosis por t\u00e9cnicas de inmunohistoqu\u00edmica (tunel) y actividad de la enzima caspasa 3.  resultados     la obstrucci\u00f3n biliar determin\u00f3 un aumento del mda y un descenso significativo del gsh y de las enzimas antioxidantes. El tratamiento con antioxidantes disminuy\u00f3 significativamente las cifras de mda e increment\u00f3 los valores de gsh y la actividad de las enzimas antioxidantes. La melatonina logr\u00f3 mayor reducci\u00f3n de mda tanto en h\u00edgado como en suero as\u00ed como un mayor aumento de gsh cuando se compar\u00f3 con la sam. Ambos antioxidantes disminuyeron las cifras de ast y alt aunque s\u00f3lo la sma consigui\u00f3 un descenso significativamente inferior en los animales tratados con melatonina frente a los que fueron tratados con  sam.  conclusiones     los animales tratados con melatonina p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s oxidativo y muerte celular en la ictericia obstructiva experimental. efecto de la melatonina y s-adenosil-metionina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s oxidativo y muerte celular en la ictericia obstructiva experimental. efecto de la melatonina y s-adenosil-metionina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luz Mar\u00eda Ramirez Ortiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Padillo Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Montilla lopez <\/li>\n<li> Guerrero montavez Juan  Miguel (vocal)<\/li>\n<li>Jos\u00e9 Luis Montero alvarez (vocal)<\/li>\n<li> Dios vega Juan  Francisco de (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luz Mar\u00eda Ramirez Ortiz Introducci\u00f3n existe evidencia en la literatura de que los radicales libres del ox\u00edgeno [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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