{"id":59623,"date":"2007-04-07T00:00:00","date_gmt":"2007-04-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-estructura-y-funcion-de-la-familia-de-protea%c2%adnas-quinasas-c\/"},"modified":"2007-04-07T00:00:00","modified_gmt":"2007-04-07T00:00:00","slug":"estudio-de-la-estructura-y-funcion-de-la-familia-de-protea%c2%adnas-quinasas-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/lipidos\/estudio-de-la-estructura-y-funcion-de-la-familia-de-protea%c2%adnas-quinasas-c\/","title":{"rendered":"Estudio de la estructura y funci\u00f3n de la familia de prote\u00ednas quinasas c"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sonia S\u00e1nchez Bautista <\/strong><\/h2>\n<p>La prote\u00edna quinasa c (pkc) participa en numerosos procesos de se\u00f1alizaci\u00f3n celular y est\u00e1 implicada en multitud de funciones fisiol\u00f3gicas como crecimiento, diferenciaci\u00f3n celular, apoptosis, respuesta inmunitaria, secreci\u00f3n hormonal, entre otras. en la presente tesis se ha estudiado el papel de la regi\u00f3n reguladora de las isoenzimas cl\u00e1sicas y nuevas. Adem\u00e1s se ha estudiado la estructura secundaria del dominio catal\u00edtico de una isoenzima at\u00edpica: la pkc zeta. dentro de la regi\u00f3n reguladora se distinguen dos dominios, el c1 que se enlaza a diacilglicerol (dag) y \u00e9steres de forbol y el dominio c2 que en las pkc cl\u00e1sicas une fosfol\u00edpidos ani\u00f3nicos en presencia de calcio y en las pkc nuevas lo hace de un modo independiente de calcio. Por su parte, el dominio catal\u00edtico contiene los sitios de uni\u00f3n del atp y del sustrato susceptible de fosforilaci\u00f3n por la pkc.Teniendo en cuenta todo lo anterior, en la presente tesis se ha estudiado: i) la afinidad de uni\u00f3n del dominio c2 alfa a fosfatidilinositol-4,5-bisfosfato (pip2), ii) c\u00f3mo cambia el \u00e1cido fosfat\u00eddico en conformaci\u00f3n y reorganizaci\u00f3n como consecuencia de la interacci\u00f3n con el dominio c2 epsilon, iii) la capacidad de uni\u00f3n de distintos dominios c1b de las isoenzimas cl\u00e1sicas y nuevas a diferentes tipos de dag y en presencia de l\u00edpidos negativos, iv) la estructura secundaria del dominio catal\u00edtico de la pkc zeta y c\u00f3mo se modula por la presencia del ligando mg2+-atp as\u00ed como su comportamiento frente a la desnaturalizaci\u00f3n t\u00e9rmica. la utilizaci\u00f3n de diferentes t\u00e9cnicas as\u00ed como diferentes mutantes nos ha permitido determinar que el dominio c2 alfa interacciona con una mol\u00e9cula de pip2 de un modo dependiente de calcio a trav\u00e9s de la regi\u00f3n rica en lisinas. Un estudio m\u00e1s extensivo utilizando diferentes tipos de fosfoinos\u00edtidos ha demostrado que la presencia de cargas negativas no es determinante en la interacci\u00f3n del dominio c2 con el fosfoinos\u00edtido sino que existe un com<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la estructura y funci\u00f3n de la familia de prote\u00ednas quinasas c<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la estructura y funci\u00f3n de la familia de prote\u00ednas quinasas c <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sonia S\u00e1nchez Bautista <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> G\u00f3mez Fern\u00e1ndez  Juan  Carmelo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felix Mar\u00eda Go\u00f1i urcelay <\/li>\n<li> Rodriguez arrondo Jos\u00e9 Luis (vocal)<\/li>\n<li>Santiago Torres mart\u00ednez (vocal)<\/li>\n<li> De godos de Francisco  Ana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sonia S\u00e1nchez Bautista La prote\u00edna quinasa c (pkc) participa en numerosos procesos de se\u00f1alizaci\u00f3n celular y est\u00e1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[964,8235],"tags":[131716,12081,8563,8564,4497,131715],"class_list":["post-59623","post","type-post","status-publish","format-standard","hentry","category-lipidos","category-murcia","tag-de-godos-de-francisco-ana","tag-felix-maria-goni-urcelay","tag-gomez-fernandez-juan-carmelo","tag-rodriguez-arrondo-jose-luis","tag-santiago-torres-Martinez","tag-sonia-sanchez-bautista"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59623","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59623"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59623\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59623"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59623"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59623"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}