{"id":59658,"date":"2007-05-07T00:00:00","date_gmt":"2007-05-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-terapeuticas-antioxidantes-sobre-la-micorcirculacion-en-el-sa%c2%adndrome-de-isquemia-reperfusion-intestinal\/"},"modified":"2007-05-07T00:00:00","modified_gmt":"2007-05-07T00:00:00","slug":"efecto-de-terapeuticas-antioxidantes-sobre-la-micorcirculacion-en-el-sa%c2%adndrome-de-isquemia-reperfusion-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/gastroenterologia\/efecto-de-terapeuticas-antioxidantes-sobre-la-micorcirculacion-en-el-sa%c2%adndrome-de-isquemia-reperfusion-intestinal\/","title":{"rendered":"Efecto de terap\u00e9uticas antioxidantes sobre la micorcirculaci\u00f3n en el s\u00edndrome de isquemia-reperfusi\u00f3n intestinal"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 P\u00e9rez-agote Iturrioz <\/strong><\/h2>\n<p>El da\u00f1o por reperfusi\u00f3n de tejidos se atribuye fundamentalmente al ataque leucocitario sobre las c\u00e9lulas endoteliales. Los f\u00e1rmacos antioxidantes han demostrado mejorar la supervivencia y reducir el da\u00f1o, pero no est\u00e1 claro su efecto sobre la circulaci\u00f3n capilar.     esta tesis doctoral aborda el problema cuantificando mediante l\u00e1ser-doppler  el flujo capilar en tres tramos diferentes del intestino reperfundido tras dos periodos diferentes de isquemia y tratados con \u00e1cido f\u00f3lico, super\u00f3xido dismutasa, alfa-tocoferol u ocre\u00f3tido. Las experiencias se llevan a cabo en ratas wag.     la simple administraci\u00f3n de dos cc de suero fisiol\u00f3gico mejora la reperfusi\u00f3n a nivel capilar, datos que se adoptan como controles para los f\u00e1rmacos ensayados. El \u00e1cido f\u00f3lico empeora el efecto del suero fisiol\u00f3gico donde la isquemia es menos intensa, es decir a nivel yeyunal, pero es claramente eficaz cuando las condiciones son de isquemia intensa (\u00edleon), a lo largo de los treinta minutos en la isquemia de 60 minutos y s\u00f3lo eficaz en la reperfusi\u00f3n inicial en la isquemia de 120 minutos. La sod tiene efectos poco uniformes sobre la microcirculaci\u00f3n tras la isquemia de 60 minutos, pero hay una clara mejor\u00eda de todos los resultados obtenidos con 120 minutos de isquemia. El aft muestra un efecto parad\u00f3jico. Tras la isquemia de 60 minutos el atf tiene efectos globales contraproducentes sobre la microcirculaci\u00f3n. Sin embargo, tras la isquemia de 2 horas, aporta beneficios claros en el yeyuno y el \u00edleon terminal, lo que no concuerda con la discreta mejora, no significativa estad\u00edsticamente, de la mortalidad encontrada en su momento, aunque s \u00ed con la capacidad de disminuir la lesividad en el \u00edleon. El octeotr\u00eddo presenta efectos beneficiosos estables, salvo en la isquemia de 60 minutos sobre yeyuno y en la isquemia de dos horas sobre \u00edleon.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de terap\u00e9uticas antioxidantes sobre la micorcirculaci\u00f3n en el s\u00edndrome de isquemia-reperfusi\u00f3n intestinal<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de terap\u00e9uticas antioxidantes sobre la micorcirculaci\u00f3n en el s\u00edndrome de isquemia-reperfusi\u00f3n intestinal <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 P\u00e9rez-agote Iturrioz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Garcia Alonso Montoya<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Mendez martin <\/li>\n<li>Carlos Vaquero puerta (vocal)<\/li>\n<li>Jes\u00fas \u00e1lvarez fern\u00e1ndez-represa (vocal)<\/li>\n<li>Jos\u00e9 Antonio Rodr\u00edguez montes (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 P\u00e9rez-agote Iturrioz El da\u00f1o por reperfusi\u00f3n de tejidos se atribuye fundamentalmente al ataque leucocitario sobre las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1279,1550,491,12909,1323],"tags":[9258,28164,10122,2338,3775,131781],"class_list":["post-59658","post","type-post","status-publish","format-standard","hentry","category-cirugia-experimental","category-cirugia-vascular","category-gastroenterologia","category-pais-vasco-euskal-herriko-unibertsitatea","category-patologia-experimental","tag-carlos-vaquero-puerta","tag-ignacio-garcia-alonso-montoya","tag-jaime-mendez-martin","tag-jesus-alvarez-fernandez-represa","tag-jose-antonio-rodriguez-montes","tag-jose-perez-agote-iturrioz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59658"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59658\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}