{"id":59708,"date":"2007-06-07T00:00:00","date_gmt":"2007-06-07T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/interaccion-entre-las-poliaminas-y-el-sistema-beta-adrenergico-en-modelo-de-miocardio-de-rata-y-en-receptores-humanos-en-diferentes-tejidos\/"},"modified":"2007-06-07T00:00:00","modified_gmt":"2007-06-07T00:00:00","slug":"interaccion-entre-las-poliaminas-y-el-sistema-beta-adrenergico-en-modelo-de-miocardio-de-rata-y-en-receptores-humanos-en-diferentes-tejidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/interaccion-entre-las-poliaminas-y-el-sistema-beta-adrenergico-en-modelo-de-miocardio-de-rata-y-en-receptores-humanos-en-diferentes-tejidos\/","title":{"rendered":"Interaccion entre las poliaminas y el sistema beta adrenergico en modelo de miocardio de rata y en receptores humanos en diferentes tejidos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Clara Meana Gonzalez <\/strong><\/h2>\n<p>Continuando con la l\u00ednea de investigaci\u00f3n llevada a cabo en nuestro laboratorio, en la que se suger\u00eda la relaci\u00f3n entre las  poliaminas y el sistema \u00edY-adren\u00e9rgico, valoramos la misma en animales experimentales, c\u00e9lulas cho (chinese ovary hamster) transfectadas con receptores \u00edY-adren\u00e9rgicos humanos, y tejido cardiaco humano, llevando a cabo para ello estudios tanto bioqu\u00edmicos como funcionales, incluyendo ensayos de ligandos, hplc, actividades enzim\u00e1ticas, enzimoinmunoensayos, estudios fenot\u00edpicos y ba\u00f1o de \u00f3rganos. En animales de experimentaci\u00f3n encontramos que las poliaminas end\u00f3genas modulan la respuesta \u00edY-adren\u00e9rgica, puesto que su disminuci\u00f3n inhibe los aumentos de ampc producidos por los agonistas \u00edY-adren\u00e9rgicos. En c\u00e9lulas, la putrescina ex\u00f3gena se comporta como un agonista \u00edY-adren\u00e9rgico no selectivo, aumentando los niveles de ampc intracelulares que a su vez se relacionan con modificaciones fenot\u00edpicas, inhibi\u00e9ndose su respuesta por \u00edY-bloqueantes o p\u00e9rdida de funcionalidad receptorial. En tejido humano, hay relaci\u00f3n entre las poliaminas end\u00f3genas espermidina y espermina y el ampc, estableci\u00e9ndose entre ambas variables una relaci\u00f3n lineal inversa en la que los niveles de poliaminas ser\u00edan los que determinaran los niveles de ampc. En modelos animales estudiamos la hipoxia por su implicaci\u00f3n en el desarrollo de cardiopat\u00edas y la hipercapnia por su activaci\u00f3n del sistema nervioso simp\u00e1tico. Hemos encontrado diferencias en los niveles intracelulares de poliaminas con respecto a situaciones fisiol\u00f3gicas. As\u00ed mismo, ambas variables produjeron modificaciones de los valores de poliaminas en estudios en c\u00e9lulas cho. En linfocitos, como modelo de estudio en humanos, las poliaminas end\u00f3genas regulan el ciclo celular,  requiriendo para ello un sistema \u00edY-adren\u00e9rgico funcionante. Nuestros resultados apoyan la existencia de una relaci\u00f3n entre las poliaminas y el sistema \u00edY-adren\u00e9rgicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Interaccion entre las poliaminas y el sistema beta adrenergico en modelo de miocardio de rata y en receptores humanos en diferentes tejidos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Interaccion entre las poliaminas y el sistema beta adrenergico en modelo de miocardio de rata y en receptores humanos en diferentes tejidos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Clara Meana Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Oviedo<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 06\/07\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Sanchez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Cortina llosa arturo agustin <\/li>\n<li>mercedes Salaices s\u00e1nchez (vocal)<\/li>\n<li> Carvajal     garcia pando alfonso (vocal)<\/li>\n<li>lucia Velasco roces (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Clara Meana Gonzalez Continuando con la l\u00ednea de investigaci\u00f3n llevada a cabo en nuestro laboratorio, en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[957,8846],"tags":[10237,131885,62834,58663,9019,5260],"class_list":["post-59708","post","type-post","status-publish","format-standard","hentry","category-farmacologia","category-oviedo","tag-carvajal-garcia-pando-alfonso","tag-clara-meana-gonzalez","tag-cortina-llosa-arturo-agustin","tag-lucia-velasco-roces","tag-manuel-sanchez-fernandez","tag-mercedes-salaices-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=59708"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/59708\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=59708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=59708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=59708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}